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EC number: 200-657-5 | CAS number: 67-51-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 July 2012 to 05 September 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, with experiments conducted according to appropriate and valid guidelines and conducted under GLP conditions.
- Qualifier:
- according to guideline
- Guideline:
- other: Particle size analysis: CTL SOP No. 417
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 13320:2009
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 187
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Deviations:
- not applicable
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- volumetric distribution
- Mass median aerodynamic diameter:
- 268.99 µm
- Geometric standard deviation:
- >= 1.482 - <= 1.486
- Key result
- Percentile:
- D50
- Mean:
- 251.932 µm
- Remarks on result:
- other: Average result is calculated from the entirety of data captured in each of the five runs and is not a simple arithmetic mean(migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.)
- Key result
- Percentile:
- D10
- Mean:
- 153.16 µm
- St. dev.:
- 0.38
- Key result
- Percentile:
- D50
- Mean:
- 251.932 µm
- St. dev.:
- 0.32
- Key result
- Percentile:
- D90
- Mean:
- 408.702 µm
- St. dev.:
- 0.94
- Conclusions:
- Under the conditions of the test, the particle size of the test material was determined to have a MMAD (mass median aerodynamic diameter) of 268.990 µm, median diameter of 251.932 µm with a geometric standard deviation of between 1.482 and 1.486. The coefficient of variation was less than 3% at d50 and less than 5% for d10 and d90, thus the repeatability of the characteristic particles in the size distribution are within the acceptability limits of the ISO 13320-1 test standards.
- Executive summary:
The particle size of the test material was determined by laser diffraction in a GLP study performed to the standardised guidelines Particle size analysis: CTL SOP No. 417, ISO 13320: 2009, CIPAC MT 187 and in consideration of the OECD guideline 110.
Under the conditions of the test, the particle size of the test material was determined to have a MMAD (mass median aerodynamic diameter) of 268.990 µm, median diameter of 251.932 µm with a geometric standard deviation of between 1.482 and 1.486. The coefficient of variation was less than 3% at d50 and less than 5% for d10 and d90, thus the repeatability of the characteristic particles in the size distribution are within the acceptability limits of the ISO 13320-1 test standards.
Reference
VISUAL MICROSCOPE OBSERVATIONS
- Standard visual observations: medium size, white powder with clusters.
- Observations at 100 x magnification: Particles appeared to be round edged crystals. The smallest individual particle was approximately 83 µm and the largest was approximately 432 µm.
- Observations at 400 x magnification: The test material was observed to be made up of single crystalline particles.
Table 1. Test Results (µm)
|
Run 1 |
Run 2 |
Run 3 |
Run 4 |
Run 5 |
Average** |
Volume weighted Mean |
267.999 |
269.148 |
267.939 |
267.940 |
268.027 |
268.211 |
Median (d.50) |
251.848 |
252.567 |
251.702 |
251.736 |
251.809 |
251.932 |
Mode (µm) |
254.033 |
254.258 |
254.058 |
254.004 |
254.123 |
254.096 |
MMAD* |
268.900 |
269.668 |
268.744 |
268.780 |
268.858 |
268.990 |
10% of material is < |
153.355 |
153.801 |
152.730 |
152.980 |
152.944 |
153.160 |
50% of material is < |
251.848 |
252.567 |
251.702 |
251.736 |
251.809 |
251.932 |
90% of material is < |
407.819 |
410.528 |
408.539 |
408.202 |
408.453 |
408.702 |
*Mass median Aerodynamic Diameter
** Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.
0.0% by volume of sample was seen to be < 10.00 µm.
Table 2. Standard Deviation Results
Run No. |
1 |
2 |
3 |
4 |
5 |
STDVP |
% STDV |
d10 |
153.355 |
153.801 |
152.730 |
152.980 |
152.944 |
0.38 |
0.25 |
d50 |
251.848 |
252.567 |
251.702 |
251.736 |
251.809 |
0.32 |
0.13 |
d90 |
407.819 |
410.528 |
408.539 |
408.202 |
408.453 |
0.94 |
0.23 |
d15.78 |
169.905 |
170.386 |
169.355 |
169.577 |
169.561 |
0.36 |
0.21 |
GSD* |
1.482 |
1.482 |
1.486 |
1.484 |
1.485 |
0.00 |
0.10 |
MMAD |
268.900 |
269.668 |
268.744 |
268.780 |
268.858 |
0.34 |
0.13 |
*Geometric standard deviation
Coefficient of variation: d50 < 3%; d10 and d90 < 5%. The repeatability of the characteristic particle in the size distribution is within the acceptability limits of the ISO 13320-1 test standards.
Description of key information
The particle size of 3,5-Dimethylpyrazole was determined in a key study (Livingston, 2012) to have a MMAD (mass median aerodynamic diameter) of 268.990 µm, median diameter of 251.932 µm with a geometric standard deviation of between 1.482 and 1.486. The study was performed to GLP and the standardised guidelines; particle size analysis: CTL SOP No. 417; ISO 13320: 2009; CIPAC MT 187 and in consideration of the OECD guideline 110.
Additional information
Livingston (2012) has been provided as the key study to address this endpoint, where the average particle size was determined by the laser diffraction method. The study was performed in line with GLP and standardised guidelines and had thus been assigned a reliability score of 1 using the principles for assessing data quality as set out in Klimisch (1997).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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