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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 207-975-3 | CAS number: 503-74-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Adsorption/Desorption
In accordance with column 2 of REACH Annex VIII Nr 9.3.1, the study does not need to be conducted as the substance has a low potential for adsorption (log Kow < 3, see Sect. 4.7) and is readily biodegradable (see Sect. 5.2.1).
Based on a calculated Koc of 4.022 (log Koc = 0.6045), isovaleric acid is expected to have a high mobility in soil (GUBDH, 2012).
Henry’s Law constant
Henry's law constants (HLC) of isovaleric acid at 25°C were determined by an experimental method (Khan, 1992; equilibrium partial pressure measurements over aqueous solutions) and by calculation methods (GUBDH,2012; program HENRYWIN v 3.2, US EPA EPISuite 4.10).
Experimental value: HLC (25°C) = 8.333E-7 atm m³/mol
Calculated Value:
Bond contribution method: HLC (25°C) = 1.28E-006 atm m³/mole
Group contribution method: HLC (25°C) = 9.96E-007 atm m³/mole
Isovaleric acid volatilizes only to a low degree from water.
Distribution modelling
Estimates obtained from Level III fugacity distribution modelling using US EPA EPI Suite v4.10, model component Level III fugacity model, indicate that emissions of isovaleric acid will distribute predominantly in soil (57%) and water (37.6%), and to a considerably lesser extent in air (5.3%). The fraction in sediment is minimal (0.07%). The estimated persistence time is 282 hr (GUBDH, 2012).
Other distribution data
Volatilization from Water
With an experimental Henry's Law Constant (HLC) of 8.333E-7 atm m³/mol at 25 °C for isovaleric acid, volatilization half-lives of 29.6 and 327 days were estimated for a model river and a model lake, respectively.
In the environment, isovaleric acid will be predominantly distributed in soil and to a lesser extend in water. Transfer to air will be minute.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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