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EC number: 605-014-6 | CAS number: 1555-62-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study under GLP without deviations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-[(2-cyanoethyl)(dodecyl)amino]propanenitrile
- EC Number:
- 605-014-6
- Cas Number:
- 1555-62-0
- Molecular formula:
- C18H33N3
- IUPAC Name:
- 3-[(2-cyanoethyl)(dodecyl)amino]propanenitrile
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand albino rabbit
- Details on test animals or test system and environmental conditions:
Species New Zealand albino rabbit
Strain Chbb: NZW (SPF)
Origin Chemical pharmaceutical factory Dr. K. Thomae 88400 Biberach
Number of animals 3
Body weight at start
of the study 2.3 - 2.5 kg
Animal maintenance in fully air-conditioned rooms in separate cages arranged in a battery
Room temperature 20 ±3°C
Relative humidity 50 ±20 %
Lighting time 12 hours daily
Acclimatization 1 week under study conditions
Food ssniff' K-H (V2333), ad libitum and hay (approx. 15 g daily)
Water water from automatic water dispensers, ad libitum
Animal identification numbered ear tags
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: 0.3 mL polyethylene glycol 400
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg per patch
- Duration of treatment / exposure:
- 4h
- Observation period:
- 10d
- Number of animals:
- 3
- Details on study design:
- About 24 hours before the start of the study the hair in the dorsal region of the body of 3 rabbits was removed with an electric clipper over an area of about 25 cm2. Only animals with intact skin were used.
Each animal was treated with 0.5 9 C12-Sternnitril pasted with 0.3 mL polyethylene glycol 400 (Riedel de Haen Aktiengesellschaft). The substance was applied over the whole surface of a 2.5 x 2.5 cm cellulose patch on a piece of surgical plaster (specially produced by Beiersdorf Aktiengesellschaft). The plaster was fixed to the prepared skin area and then covered with a semi-occlusive bandage.
The exposure period was 4 hours. After the exposure period all remnants of the test substance were carefully removed from the skin with warm tap water.
Examinations of the skin took place after 30 - 60 minutes as well as 24, 48 and 72 hours after removal of the patches. Because of persistent irritations 72 hours after removal of the patches, additional readings were performed after 7 and 10 days.
Erythema, eschar formation and oedema were evaluated numerically according to the score of DRAIZE . All other changes of the skin were recorded.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h, 7d, 10d
- Score:
- 1.9
- Max. score:
- 3
- Reversibility:
- fully reversible within: 10d
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h, 7d, 10d
- Score:
- 0.2
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48h
- Irritant / corrosive response data:
- 30 - 60 minutes up to 72 hours after removal of the plaster the animals showed very slight up to moderate erythema. Very slight oedema occurred in two animals 24 hours after removal of the plaster. 7 days after removal of the plaster a very slight erythema was observed in one animal. 10 days after removal of the plaster all signs of irritation were reversible. Additionally, the treated skin surface were sporadically dry, rough and coarse scaly as well as desquamation of coarse scales were noted.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of this OECD404 study N,N-Di-(2-cyanoethyl)-dodecylnitril is irritating to skin.
- Executive summary:
Based on the results of this OECD404 study N,N-Di-(2-cyanoethyl)-dodecylnitril is irritating to skin.
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