Registration Dossier
Registration Dossier
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EC number: 201-924-9 | CAS number: 89-62-3
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- other: Database
- Title:
- 2-Nitro-4 -methyl analine
- Author:
- RepDose Online Database
- Year:
- 2 011
- Bibliographic source:
- RepDose Online Database of Fraunhofer ITEM;BG Chem. Toxicol. Eval. 118,
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from Repdose database.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-nitro-p-toluidine
- EC Number:
- 201-924-9
- EC Name:
- 2-nitro-p-toluidine
- Cas Number:
- 89-62-3
- Molecular formula:
- C7H8N2O2
- IUPAC Name:
- 4-methyl-2-nitroaniline
- Details on test material:
- - Name of test material: 2-nitro-p-toluidine
- Molecular formula: C7H8N2O2
- Molecular weight: 152.15
- Substance type: organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 28 days
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- NOEL
- Effect level:
- 40 other: mg/kg bw/d
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: urea/nitrogen, water intake,erythrocytes, weight increase, discoloration, volume
- Dose descriptor:
- LOEL
- Effect level:
- 1 000 other: mg/kg bw/d
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: urea/nitrogen, water intake,erythrocytes, weight increase, discoloration, volume
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Repeated dose toxicity (4 weeks) value of 2-nitro-p-toluidine to rat(male/female) is found to be NOEL: 40 mg/kg bw/d and LOEL:1000mg/kg bw/d.
- Executive summary:
Repeated dose toxicity (4 weeks) value of 2-nitro-p-toluidine to rat(male/female) is found to be NOEL: 40 mg/kg bw/d and LOEL:1000mg/kg bw/d.
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