Registration Dossier
Registration Dossier
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EC number: 247-988-1 | CAS number: 26762-93-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other:
- Remarks:
- Industrial Biotest Laboratory was found to use fraudulent practices in some of their studies and reports. Since these studies were performed before the implementation of Good Laboratory Practices, it is not possible to verify the scientific credibility of most of these studies.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Reference Type:
- review article or handbook
- Title:
- Organic peroxides
- Author:
- Patty's Industrial Hygiene and Toxicology
- Year:
- 1 993
- Bibliographic source:
- Volumes II part A: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., p. 582 and 587
Materials and methods
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diisopropylbenzene hydroperoxide
- EC Number:
- 247-988-1
- EC Name:
- Diisopropylbenzene hydroperoxide
- Cas Number:
- 26762-93-6
- Molecular formula:
- C12H18O2
- IUPAC Name:
- reaction mass of 1-(3-isopropylphenyl)-1-methylethyl hydroperoxide and 1-(4-isopropylphenyl)-1-methylethyl hydroperoxide
- Test material form:
- liquid
- Details on test material:
- SMILES : [*]OO.[*]C(C)C.CC(C)c1ccccc1
Molecular formula: C12H18O2
Molecular Weight: 196.288
Constituent 1
- Specific details on test material used for the study:
- Diisopropylbenzene hydroperoxide : 55%
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 6
- Concentrations:
- 2.18, 4.26, and 5.59 mg/l (nominal)
Results and discussion
Effect levels
- Dose descriptor:
- LC50
- Effect level:
- 4.5 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 6 h
Applicant's summary and conclusion
- Executive summary:
An acute inhalation study using rats exposed to the nominal concentrations of 2.18, 4.26, and 5.59 mg/l caused red nasal discharge at even the lowest dose. The animals also showed signs of shortness of breath, reduced activity, and vasodilitation. Fifty percent of the animals exposed to the 4.26 mg/l level died showing similar symptoms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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