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EC number: 213-485-0 | CAS number: 957-68-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 20th September 1978 to 11th October 1978
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 3-acetoxymethylen-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- EC Number:
- 213-485-0
- EC Name:
- 3-acetoxymethylen-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Cas Number:
- 957-68-6
- Molecular formula:
- C10H12N2O5S
- IUPAC Name:
- (6R,7R)-3-[(acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- 7-Aminocephalosporansäure Op. 109/78
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Weight of six male rats: 225 g - 244 g
Weight of six female rats: 223 g - 245 g
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- The rats were exposed individually in cylindrical synthetic cages - with defined dust concentrations. The synthetic tubes leading to the exposure cylinder, are arranged in that way that only the noses of the animals are located inside the cylinder. The inhalation chamber itself consists of a 60 liter glass-and stainless steel cylinder which is in a fume hood. To avoid the in the dispersion of the dust occurring electric charges and the resulting agglomeration the exposure cylinder is grounded. At the bottom of the inhalation chamber a suction device with which the dust-air mixture was extracted at a vacuum of 1700 L/hour over a Ciber cotton wool filter and a wash bottle filled with water. The dust exiting by the gauge pressure out of the inhalation chamber was sucked into a gas purification plant, in which the complete detoxication occurred. As dust generator a modified Exactomat 3 B of A. Platsch, Stuttgart-Vaihingen was used. The dust produced by the vibratory feeder was directed by an air volume of 1500 L/hour into the exposure chamber.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- Group 1: 0.90 - 1.34 g 7-ACA/mE03
Group 2: 1.44 - 2.11 g 7-ACA/mE03 - Control animals:
- no
- Details on study design:
- During the inhalation the animals' behavior was observed and recorded accurately. After the inhalation, the animals were kept for 14 days under observation. During this follow-up period in which the animals were kept in synthetic cages on softwood pellets, they received tap water for drinking and ALTROMIN 1324 of the company Altromin GmbH, Lage / Lippe. The animals were killed after the follow-up period under anesthesia, dissected and examined macroscopically. The aerosol dust concentration in the inhalation chamber was determined gravimetrically.
Results and discussion
- Mortality:
- No animals were dead after exposure.
- Clinical signs:
- other: The rats showed accelerated breathing and closed palpebral fissures.
- Body weight:
- All rats of group 1 and the male rats of group 2 showed a normal body weight developement in 14 days after exposure. The female rats of group 2 showed an irregular body weight developement in 14 days after exposure. They did not reach their body weight before exposure.
- Gross pathology:
- No macroscopical findings.
Applicant's summary and conclusion
- Conclusions:
- All animals survived the exposure for 4 hours. The rats showed accelerated breathing and closed palpebral fissures. The autopsy of killed animals after exposure showed no macroscopical findings.
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