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EC number: 611-025-7 | CAS number: 53651-69-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Development and validation of an alternative dermal sensitization test: the mouse ear swelling test (MEST)
- Author:
- Gad S.C., Dunn B.J., Dobbs D.W., Reilly C. and Walsh R.D.
- Year:
- 1 986
- Bibliographic source:
- Toxicology and applied pharmacology 84, 93-114
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No guideline was available at the time the study was performed; the study was part of the development and validation of the mouse ear swelling test (MEST).
- Short description of test conditions:
CF-1 female mice, 6 to 8 weeks old, were shaved and tape stripped at the start of each study. As a standard part of this design, two id injections totalling 0.05 mL of FCA were performed into the stomach induction site of unanaesthetised mice prior to the first induction application. All mice were then topically dosed with 100 µL of test material in solvent or solvent alone (for controls) applied to the center of the shaved region. s returned to its cage. The application was allowed to dry before the animal was returned to its cage.
Tape stripping and topical application of the appropriate solution to the stomach were repeated for three additional consecutive days. Seven days after the final topical application to the stomach, 20 µL of test compound in solution was applied to the left ear of each animal (test and control), and 20 µL of the solvent was applied to the right ear. At both 24 and 48 hr after this challenge, animals were lightly anesthetized with ether and the thicknesses of both ears measured. As an additional guard against false positives, should it be felt necessary, ear thicknesses may also be measured the day before challenge to protect against the small random chance of a naturally occurring “difference” in test or control groups. - GLP compliance:
- no
- Type of study:
- mouse ear swelling test
- Justification for non-LLNA method:
- Study pre-dates validation of LLNA protocol.
Test material
- Reference substance name:
- Propan-1-ol
- EC Number:
- 200-746-9
- EC Name:
- Propan-1-ol
- Cas Number:
- 71-23-8
- Molecular formula:
- C3H8O
- IUPAC Name:
- 1-propanol
1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CF-1
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: CF-1 female mice from Charles River Breeding Laboratories
- Age at study initiation: 6 to 8 weeks old,
- Weight at study initiation:
- Housing: five per cage in wire-bottom stainless-steel cages
- Diet: ad libitum, Purina Rodent Laboratory Chow 5001
- Water: ad libitum
- Acclimation period: 5 days
- Indication of any skin lesions: animals were screened to remove any from testing that have ears that appear red or swollen (due to infection or mishap).
ENVIRONMENTAL CONDITIONS
- not reported
Study design: in vivo (non-LLNA)
- No. of animals per dose:
- 10-15
- Details on study design:
- CF-1 female mice, 6 to 8 weeks old, were shaved and tape stripped at the start of each study. As a standard part of this design, two id injections totaling 0.05 mL of FCA were performed into the stomach induction site of unanesthetized mice prior to the first induction application. A 1-cc tuberculin syringe with a 30-gauge needle was used in each of 10 or 15 test mice and 5 or 10 control mice (the larger number being used when there was concern about systemic toxicity a&r the probe study). All mice were then topically dosed with 100 µL of test material in solvent or solvent alone (for controls) applied to the center of the shaved region. The application was allowed to dry before the animal was returned to its cage. Tape stripping and topical application of the appropriate solution to the stomach were repeated for three additional consecutive days. Seven days after the final topical application to the stomach, 20 µL of test compound was applied to the left ear of each animal (test and control), and 20 µL of the solvent was applied to the right ear. At both 24 and 48 hr after this challenge, animals were lightly anesthetized with ether and the thicknesses of both ears measured. As an additional guard against false positives, should it be felt necessary, ear thicknesses may also be measured the day before challenge to protect against the small random chance of a naturally occurring “difference” in test or control groups.
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 100%
- Total no. in group:
- 10
- Remarks on result:
- no indication of skin sensitisation
- Remarks:
- 101% ear swelling compared to control
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 100%
- Total no. in group:
- 10
- Remarks on result:
- no indication of skin sensitisation
- Remarks:
- 101 % Ear Swelling compared to control
Any other information on results incl. tables
MEST results for propanol: 0% sensitized and 101% swelling. The substance is no skin sensitizer. The publication lists no sensitisation of propanol in GMPT, Closed patch type tests and Human results.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP criteria not met
- Conclusions:
- The test substance propanol (100%) was found as not sensitising in the non-guideline study (Mouse Ear Swelling Test (MEST)) conducted on CF-1 mice.
- Executive summary:
Propanol (100%) was tested in non-guideline in vivo sensitization study (Mouse Ear Swelling Test ) conducted on CF-1 female mice. Prior to topical induction with 100 µL test material, 10 -15 female CF-1 mice were shaved, and tape stripped and intradermally injected twice with 0.05 mL FCA into the stomach induction site.
Tape stripping and topical application of the appropriate solution to the stomach were repeated for three additional consecutive days. Seven days after the final topical application to the stomach, 20 µL of test compound was applied to the left ear of each animal (test and control), and 20 µL of the solvent was applied to the right ear. Measurements of ear thickness were performed at both 24 and 48 hours after challenge. MEST results for propanol indicated no sensitisation in mice (0% sensitized) and ear swelling comparable to controls (101% swelling). Based on the results of this study, the test substance propanol (100%) was not a skin sensitizer.
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