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Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 204-877-2 | CAS number: 128-08-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance is readily biodegradable
- other:
- Justification for type of information:
- Statement:
According to the guidelines, the hydrolysis as a function of pH test is performed to determine the rate of hydrolysis of the test substance as a function of pH. On the one hand, the study is applicable to chemical substances for which an analytical method with sufficient accuracy and sensitivity is available. On the other hand, the method should be also selective enough to differentiate the test item from any possible co-eluting hydrolysis products. In order to achieve that, a chromatographic method must be developed and used with suitable detection.
Based on chemical knowledge, it is expected that any hydrolysis or/of dissociation product would be at least as polar as the test item and the latter will co-elute with its hydrolysis product in reversed-phase liquid chromatography. Therefore, a more selective detection e.g. MS detection would be necessary in order to improve the selectivity and clearly differentiate the test item from its co-eluting hydrolysis products.
In project No. 504968 “Development and validation of an analytical method for the analysis of succinimide, hydrolysis product of N-BROMOSUCCINIMIDE, in M2-medium,” an attempt was made to develop a LC-MS method but it turned out to be technically not possible.
In Project No. 518395 “Development and validation of an analytical method for the analysis of N-BROMOSUCCINIMIDE, in ISO-medium,” a sensitive GC-MS method was developed and validated for analysis of N-BROMOSUCCINIMIDE. However, it was also indicated that during the injection in the conditions of high temperature, the hydrolysis product succinimide is generated. As a consequence, the detection of the test item was based on the detection of its hydrolysis product succinimide. Because the test item N-BROMOSUCCINIMIDE cannot be differentiate from its hydrolysis product succinimide, this analytical method is not suitable for supporting a hydrolysis study.
In conclusion, it is technically not possible to differentiate between N-BROMOSUCCINIMIDE and its hydrolysis product using chromatographic techniques.
A prediction of hydrolysis using HYDROWIN v2.00 (included in EPI Suite, v4.11) was not possible: "Rate constants can NOT be estimated for this structure"
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.