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Diss Factsheets
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EC number: 244-007-9 | CAS number: 20749-68-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: similar to respective guideline but reported only in brief
Data source
Reference
- Reference Type:
- other: short report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
- Principles of method if other than guideline:
- 100 mg of the test substance was applied into the concunctival sac of the left eye of each of 2 rabbits. After one minute the left eye of one of the two rabbits was rinsed with physiological saline. The right eyes of each of the two rabbits served as control. The animals were observed for 7 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- 8,9,10,11-tetrachloro-12H-phthaloperin-12-one
- EC Number:
- 244-007-9
- EC Name:
- 8,9,10,11-tetrachloro-12H-phthaloperin-12-one
- Cas Number:
- 20749-68-2
- Molecular formula:
- C18H6Cl4N2O
- IUPAC Name:
- 8,9,10,11-tetrachloro-12H-isoindolo[2,1-a]perimidin-12-one
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- IUCLID4 Test substance:
pure technical product
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- one left eye : due to rinsing: 1 min, the other left eye was not rinsed
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- 100 mg of the test substance was applied into the concunctival sac of the left eye of each of 2 rabbits. After one minute the left eye of one of the two rabbits was rinsed with physiological saline. The right eyes of each of the two rabbits served as control. The animals were observed for 7 days.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: irritational effects
- Basis:
- mean
- Time point:
- other: up to 8h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- other: slight conjunctival injections which do not lead to classification
- Irritant / corrosive response data:
- After 4 hours and after 8 hours slight conjunctival injections and slight discharge was observed. Within 24 hours both left treated eyes cleared and dis charge ceased wether it was rinsed eye or not-rinsed eye. Fluorescein test was without finding.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
100 mg of the test substance was applied into the concunctival sac of the left eye of each of 2 rabbits. After one minute the left eye of one of the two rabbits was rinsed with physiological saline. The right eyes of each of the two rabbits served as control. The animals were observed for 7 days. Four hours and 8 hours post application slight irritating effects were observed which were fully reversible within 24 hours, thus, not leading to classification. In addition, Fluorescein Test was without finding. Therefore, the overall evaluation is that Macrolex Rot is not irritating to the eyes of rabbits.
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