Methyl p-toluate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1982

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: well performed study according to acknowledged rule

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1982

Report date:

1982

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: company SOP

Principles of method if other than guideline:

The animals were exposed to an air / substance - mixture

GLP compliance:

no

Test type:

other: Zeitsättigungstest

Test material

Test material information

Constituent 1

Reference substance name:

Methyl p-toluate

EC Number:

202-784-1

EC Name:

Methyl p-toluate

Cas Number:

99-75-2

Molecular formula:

C9H10O2

IUPAC Name:

methyl 4-methylbenzoate

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: males: 181 - 190 g; females: 180 - 189 g
- Housing: plastic cages
-During observation period: Diet: Altromin 1324, ad libitum
- During observation period: Water: Tap water, ad libitum

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22.4 - 25.9
- Humidity (%): 10 - 39.4

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

nose only

Vehicle:

air

Details on inhalation exposure:

120 g of the test substance was filled in a gas-washing-bottle. An air stream of 600 L / hours was blown through this gas washing-bottle into the exposure-cylinder. The pipes leading from the gas washing-bottle into the exposure cylinder were constructed in that way, that only the noses of the animals were inside this cyclinder

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

7 h

Concentrations:

2.06 g of the test item were blown into the exposure cylinder during 7 hours

No. of animals per sex per dose:

6 males and 6 females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: daily and weighing: once a week
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Mortality:

no

Clinical signs:

other: no

Body weight:

normal development

Gross pathology:

no findings

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

No symptoms of inhalative toxicity observed

Executive summary:

6 male and 6 female Wister rats were exposed during 7 hours to an air / substance mixture containing 2.06 g of the test item in the so called "Zeitsättigungstest". No mortality occured and no clinical signs were observed in the 14 days observation period and the development of the body weight was normal..