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Diss Factsheets
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EC number: 213-139-9 | CAS number: 926-63-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Skin absorption of the industrial catalyst dimethylethylamine in vitro in guinea pig and human skin, and of gaseous dimethylethylamine in human volunteers
- Author:
- Lundh T, Bowan A, Akesson B
- Year:
- 1 997
- Bibliographic source:
- Int Arch Occup Environ Health 70: 309-313
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Skin absorption of dimethylethylamine in vitro was determined with human skin samples.
- GLP compliance:
- no
Test material
- Reference substance name:
- Ethyldimethylamine
- EC Number:
- 209-940-8
- EC Name:
- Ethyldimethylamine
- Cas Number:
- 598-56-1
- Molecular formula:
- C4H11N
- IUPAC Name:
- N,N-dimethylethanamine
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- human
- Strain:
- other: Caucasian
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Human split-thickness skin (250 µm) was obtained at surgery from three Caucasian adults (two women aged 30 and 38 years, and one man of unknown age) and stored at 4 °C in sterile compresses wetted with isotonic saline solution less than 24 h prior to use. The skin was mounted in Teflon flow-through cells (Vangard International, Neptune, N.J.; Bronaugh 1991). Before exposure, the skin was left to acclimatize for 1 hour.
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- other: water or isotonic saline solution
- Doses:
- 100 µL of 1% solution (0.67mg/mL)
- No. of animals per group:
- not applicable
- Control animals:
- no
- Details on in vitro test system (if applicable):
- DMEA was diluted to 1% (i.e. 0.67 mg/mL) with water or isotonic saline solution and 100 µL of the solution were applied to the skin surface.
The perfusion medium, Hanks balanced salt solution was supplied at a flow rate of 1.5 mL/hour using a peristaltic pump (Alitea, Stockholm. Sweden) to ensure skin conditions. Using a fraction collector (Gilson 202, France) the perfusion fluid was collected at 2h-intervals for 48 h in vials containing 100 µL of 1 M hydrochloric acid (HCl 37% Merck, Darmstadt, Germany). The steady-state flux (Jss) was calculated from the slope of the linear portion of the plot of cumulative amount penetrated/cm² versus time for each cell. The permeability coefficient (Kp) at apparent steady state or at the peak absorption rate was calculated according to Fick's law as: Kp =Jss/C where Kp is the permeability coefficient (cm/ h), Jss the steady-state flux (mg/cm² x h) and C the concentration of penetrating chemical in the medium (mg/cm²).
Remark:
The uptake of DMEA in the in vivo experiments and the DMEA content in the perfusion fluid collected in the in vitro experiments were expressed as the combined amount of DMEA and DMEAO (E-DMEA).Day-to-day variations (relative standard deviations) based on nine analyses of spiked perfusion fluid specimens containing 0.51 µg/mL DMEA was 5.1%. The corresponding value for urine analyses with a concentration of 0.047 µg/ml was 8.1%.
Results and discussion
- Absorption in different matrices:
- DMEA penetrated human skin. The median Jss and Kp were 0.017 mg/cm² x h and 0.003 cm/h, respectively, for split-thickness human skin. No DMEAO could be found in the perfusion medium.
Percutaneous absorption
- Key result
- Dose:
- 1%
- Parameter:
- other: permeability coefficient (Kp)
- Remarks on result:
- other: 0.003cm/h for human skin
Any other information on results incl. tables
The steady-state flux permeability coefficient (Kp) and the lag-time obtained in the in vitro experiments.The respective medians from each experiment are based on data obtained from six flow-through cells | |||||||
Experiment n° | Jss (mg/cm² x h) | Kp (cm/h) | Lag-time (h) | ||||
Mean | Range | Mean | Range | Mean | Range | ||
Human skin | 1 | 0.026 | (0.018 0.029) | 0.004 | (0.003-).004) | Neg | |
2 | 0.011 | (0.007-0.026) | 0.002 | (0.001-0.004) | Neg | ||
3 a | 0.016 | (0.011-0.019) | 0.002 | (0.002-0.003) | 1 | (1-4) | |
a DMEA diluted with isotonic saline solution | |||||||
b Negative, the curve shape did not allow lag-time calculation |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.