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EC number: 203-479-6 | CAS number: 107-29-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Not GLP and not according to international test guideline. No detailed information about the protocol present.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Twenty-five young adult albino rats (Wistar derived) weighing between 200-300 grams were administered a dose of acetaldehyde oxime via intragastric intubation. The animals were observed for 14 days following administration of the test material and deaths were recorded.
- GLP compliance:
- no
- Remarks:
- Study from 1975
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age: young adults
- Weight at study initiation: 200-300 g
- Fasting period before study: 24 h prior to dosing
- Housing: mesh bottom cages
- Diet: ad libitum
- Water: ad libitum - Route of administration:
- oral: gavage
- Doses:
- 0.31, 0.63, 1.25, 2.50, 5.0 mL/kg
- No. of animals per sex per dose:
- 3 males and 2 females per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily - Statistics:
- The acute oral toxicity LD50 for rats was calculated according to the method of Miller and Tainter (1944, Proc. Soc. Biol. Med. 57, 261).
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1.2 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50 for 50% solution of AAO in water.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 0.6 mL/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: LD50 for AAO (undilluted)
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information
- Conclusions:
- The approximate acute oral LD50 obtained for the 50% AAO solution in water is 1.20 mL/kg body weight as estimated by interpolation from the probit response curve. The LD50 for pure AAO is 0.6 mL/kg bw.
- Executive summary:
25 young adult albino rats (Wistar derived) weighing between 200 -300 g were distributed into 5 dosage groups with 3 males and 2 females in each group. The animals were fasted 24 h prior to dosing. The test material was administered by oral gavaging. The animals were observed daily for 14 days following the adminitration of the test material.
The approximate acute oral LD50 obtained for the test material is 1.20 mL/kg body weight as estimated by interpolation from the probit response curve.
Reference
Dosage Level (mL/kg) | Mortality after 14 days |
0.31 | 0/5 |
0.63 | 0/5 |
1.25 | 3/5 |
2.50 | 5/5 |
5.0 | 5/5 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 580 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not GLP but performed according to a US regulation.
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CFR 1500.40
- GLP compliance:
- no
- Remarks:
- Study performed in 1975
- Limit test:
- no
- Species:
- rabbit
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: adult
- Source: selected from healthy, acclimated animals - Type of coverage:
- not specified
- Doses:
- 0.02, 0.2, 0.43, 0.928, 2.0 g/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Other examinations performed: examination of toxicological and pathological signs - Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD0 for 50% solution of AAO in water.
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- 1 000 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: LD0 for AAO (undilluted)
- Gross pathology:
- No effects
- Conclusions:
- The acute dermal LD50 of acetaldehyde oxime is > 2.0 g/kg body weight when tested on rabbits with intact skin. It produced no gross toxicological or pathological effects.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Oral
For acute toxicity via the oral route, there are two study reports available (Smith and Bailey 1975 (K2); Morgareidge and Bailey 1974 (K4)). In the key study (Smith and Bailey 1975), the LD50 was determined to be 0.60 mL AAO/kg bw (0.58 g/kg bw). In the supporting study (Morgareidge and Bailey 1974), an LD50 lower than 2.5 mL/kg bw was observed.
Inhalation
There is only a concise study report available for acute toxicity via the inhalation route (Shelanski and Levenson 1974). Due to unclarities on the test protocol, this study has been assigned a K4 Klimisch score. Sherman-Wistar albino rats were exposed for 1 h to a nominal concentration of 2.85 mg AAO/L. No mortalities were recorded at this dose level.
Dermal
One study report is available for acute toxicity via the dermal route (Smith and Bailey 1975 (K2)). AAO did not produce gross toxicological or pathological effects when applied on the intact skin of rabbits up to a level of 1 g/kg bw. Consequently, the acute dermal LD50 is > 1 g/kg bw.
Justification for selection of acute toxicity – oral endpoint
K2 study.
Justification for selection of acute toxicity – inhalation endpoint
Only a K4 study available.
Justification for selection of acute toxicity – dermal endpoint
K2 study.
Justification for classification or non-classification
Oral
The test substance has an ATE of 580 mg/kg body weight. According to CLP (Annex I, Table 3.1.1), substances with an ATE > 300 and ≤ 2000 mg/kg bw should be classified for acute oral toxicity in Category 4.
Dermal
The test substance did not show adverse effects at the highest tested dose of 1000 mg/kg bw. Therefore, based on the available information, AAO does not require classification for acute dermal toxicity. As the upper limit for classification according to CLP is 2000 mg/kg bw, the rationale for non-classification is "data lacking".
Inhalation
No mortalities were recorded at the tested dose of 2.85 mg of AAO per liter of air. Therefore, based on the available information, AAO does not require classification for acute dermal toxicity. As the upper limit for classification according to CLP is 5.0 mg/L, the rationale for non-classification is "data lacking"
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