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EC number: 204-409-7 | CAS number: 120-57-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1982
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- The Inhibition of Rat Nasal Cytochrome P-450-dependent mono-oxygenase by the Essence Heliotropin (Piperonal)
- Author:
- Dahl AR
- Year:
- 1 982
- Bibliographic source:
- Drug Metabolism and Disposition. 1982;10(5):553-554
Materials and methods
- Objective of study:
- other: Test for the ability of heliotropin to inhibit cytochrome P450-mediated oxidation reactions.
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The effects of heliotropin on cytochrome P450-mediated oxidative reactions were evaluated in vitro in rat nasal and liver microsomes.
- GLP compliance:
- no
Test material
- Reference substance name:
- Piperonal
- EC Number:
- 204-409-7
- EC Name:
- Piperonal
- Cas Number:
- 120-57-0
- Molecular formula:
- C8H6O3
- IUPAC Name:
- 1,3-benzodioxole-5-carbaldehyde
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Heliotropin
- Analytical purity: 99%
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Lovelace Inhalation Toxicology Research Institute
- Age at study initiation: 12 to 16 weeks
Further details were not reported.
Administration / exposure
- Route of administration:
- other: in vitro
- Vehicle:
- other: A vehicle was used but its identity was not reported.
- Details on exposure:
- Heliotropin (3 mM) was incubated with nasal and liver microsomes for 30 minutes at 37°C to evaluate its possible effect on oxidative metabolism of methyl N-methylanthranilate (DMA). Further details were not reported.
- Duration and frequency of treatment / exposure:
- 30 minute incubation period.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
3 mM
- No. of animals per sex per dose / concentration:
- Not applicable
- Control animals:
- other: Not applicable
- Positive control reference chemical:
- Not applicable
- Details on study design:
- Heliotropin (3 mM) was incubated with nasal and liver microsomes for 30 minutes at 37°C to evaluate its possible effect on oxidative metabolism of methyl N-methylanthranilate (DMA). Further details were not reported.
- Details on dosing and sampling:
- No details provided.
- Statistics:
- Not required.
Results and discussion
Main ADME results
- Type:
- other: Inhibition
- Results:
- Heliotropin inhibited CYP450 activity in nasal, but not liver, microsomes.
Any other information on results incl. tables
Table 1: Percentage of DMA Metabolism in the Presence of Heliotropin Comapred to Control |
|
Microsomes |
Heliotropin |
Nasal |
23.1 ± 0* |
Liver |
83.6 ± 2.6 |
* Probability that rates are the same as control < 0.05 (N=2) |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: Heliotropin inhibited CYP450 activity in nasal but not liver microsomes.
Heliotropin inhibited CYP450 activity in nasal but not liver microsomes. - Executive summary:
This study demonstrated that incubation with heliotropin (3 mM) inhibited CYP450-mediated oxidative metabolism of methyl N-methylanthranilate by rat nasal microsomes. No such inhibition was observed in rat liver microsomes. These data suggest that heliotropin may exert an inhibitory effect on nasal, but not liver, CYP450-mediated oxidation reactions.
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