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EC number: 252-575-4 | CAS number: 35453-19-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 1990
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Only a limit test at 2000 mg/kg was carried out
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- yes
- Remarks:
- Only a limit test at 2000 mg/kg was carried out
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 5-amino-2,4,6-triiodoisophthalic acid
- EC Number:
- 252-575-4
- EC Name:
- 5-amino-2,4,6-triiodoisophthalic acid
- Cas Number:
- 35453-19-1
- Molecular formula:
- C8H4I3NO4
- IUPAC Name:
- 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid
- Details on test material:
- Test substance was stored at room temperature in the dark in a closed cabinet.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young adult male and female Sprague-Dawley rats from BRL (Switzerland) were used. The average weight of the animals at the beginning of the treatment was 200 g +/- 10% for males and 180 g +/- 10% for females.
Rats were housed by groups of 2 or 3 of the same sex in Makrolon type III cages. The animal room was located in the B building (basement) of Battelle-Geneva.
Except for the periods of starvation as defined in the protocol, rats received food 8kliba, Kaiseraugst, ref. 24-343) and water (tap water, from a water bottle) ad libitum.
Rats were placed on a sawdust bedding in their cages.
Animals were identified individually with an ear tattoo. The animal numbers were sequential.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- and distilled water
- Details on dermal exposure:
- The test substance was prepared as follows for dermal application:
For each animal the quantity of solid test substance was weighed in order to obtain a dose of 2000 mg/kg according to the body weight measured just before treatment.
Each dose of test substance was mix in a mortar with 100 mg of carboxy-methyl-cellulose (CMC) then the mixture was moistened with distilled water in order to obtain a semi-fluid paste to ensure good contact with the skin.
The paste was applied on the shaved skin of the back of the rats and covered with a porous gauze dressing and a non-irritating tape for 24 hours. - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males
5 females - Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were examined every day post treatment for clinical observation and they were individually weighed once a week during the observation period and terminal body weights were recorded at necropsy.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, necropsy findings - Statistics:
- The only statistical analyses which were performed are ANOVA t-tests on body weights between the treated groups and the room control to verify whether the growth curve of the animals is affected by the treatment. The results of these statistical analyses are stored in the Study Archives with the raw data.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality at 2000 mg/kg
- Clinical signs:
- other: Transient redness of the skin after application in both sexes and hyperexcitability in females for 3 to 5 days, then recovery thereafter.
- Gross pathology:
- Presence of a mass on left uterine horn in 1 female, not related to treatment. No abnormal findings.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- There were no evidence of acute dermal toxicity after performing the clinical test.
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