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EC number: 282-208-3 | CAS number: 84144-87-6 Flue dust and ash containing vanadium resulting from the combustion of vanadium-bearing fuel oil.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28.04.2010 - 05.05.2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GPL guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD guideline 431
- GLP compliance:
- yes
Test material
- Reference substance name:
- Ashes (residues), vanadium-contg.
- EC Number:
- 282-208-3
- EC Name:
- Ashes (residues), vanadium-contg.
- Cas Number:
- 84144-87-6
- Molecular formula:
- Not available
- Reference substance name:
- Vanadium concentrate
- IUPAC Name:
- Vanadium concentrate
- Details on test material:
- - Name of test material (as cited in study report): vanadium concentrate
- Preparation date: 07/2009
- Expiry date: 30. Sept. 2011
- Batch No.: 14-45810
Constituent 1
Constituent 2
Test animals
- Species:
- other: in vitro, human skin modell
- Strain:
- other: not applicable (in vitro membrane test)
- Details on test animals or test system and environmental conditions:
- Not applicable: in vitro membrane test with human skin model.
Cell line:
Reconstructed Human Epidermis (EPISKIN). Kit of 12 units, age day 17 (supplied by SkinEthics)
Preperation of skin model:
At arrival, human skin was inspected for color or agar medium: orange color was verified. The temperature indicator was also inspected to verify that kit has not been exposed to a temperature above 40 °C. After arrival, inserts of human skin model were transferred in 1 ml of Maintenance Medium and incubated for 3 h at 37 +- 1 °C at 5 % CO2.
All culture media and reagents are in balance with room temperature when in contact with human skin.
Test system
- Type of coverage:
- other: not applicable (in vitro membrane test)
- Preparation of test site:
- other: not applicable (in vitro membrane test)
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- Substance is used as it is.
For solid materials, sufficient test substance was applied evenly to cover the skin, and it was moistened with deionised or distilled water to ensure good contact with the skin. - Duration of treatment / exposure:
- 3 min and 1 h at 37+- 1 °C and 5 % CO2
- Observation period:
- not applicable
- Number of animals:
- not applicable (in vitro membrane test)
- Details on study design:
- Positive control: KOH 8 N (CAS: 1310-58-3); reference substance is used as it is.
Negative control: sterile distilled water
Treatment:
Three tissue replicates are used for each sample treatment, two for positive control and one for the negative one. For solid materials, sufficient test substance was applied evenly to cover the skin, and it was moistened with deionised or distilled water to ensure good contact with the skin. The plates were incubated for 3 min and 1 h at 37 +- 1 °C at 5% CO2
MTT cell viability evaluation:
At the end of the exposure period, the test material was washed with DPBS for twenty times from the skin surface. Every tissue replicates was treated in 0.3 ml of MTT solution 1 mg/ml. The plate was incubated for 3h at 37 +- 1 °C at 5 % CO2. At the end of incubation each tissue insert was treated with 2 ml of Isopropyl alcohol (dark, T room, overnight). Two replicates of extract solution (200 µl) were put into microplates's wells and the optical density (OD) of the extracted (solubilised) dye at 570 nm was evaluated.
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- other: other: MTT cell viability evaluation
- Value:
- 98.54
- Remarks on result:
- other:
- Remarks:
- Basis: mean. Time point: 3 min treatment. Reversibility: other: not applicable. (migrated information)
- Irritation / corrosion parameter:
- other: other: MTT cell viability evaluation
- Value:
- 98.46
- Remarks on result:
- other:
- Remarks:
- Basis: mean. Time point: 1 h treatment. Reversibility: other: not applicable. (migrated information)
Any other information on results incl. tables
Table 1: Cell viability (%)
Contact time |
3 min |
1 h |
KOH 8N |
9.03 |
0.28 |
Sample |
98.54 |
98.46 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to OECD 431 "In vitro Skin Corrosion Human Skin Model test" sample resulted not corrosive to the skin.
- Executive summary:
Skin corrosive properties of Vanadium concentrate were assessed in an human skin model (EpiSKIN) according to OECD 431. Sufficient test substance was applied evenly to cover the skin, and it was moistened with distilled water to ensure good contact. The plates were incubated for 3 min and 1 h at 37 °C. Afterwards, a MTT cell viability test evaluation was conducted.
It was verified that the mean viability (respect negative control) of the two replicates of positive control was ≤ 20 % after 1h. The mean OD value of the two replicates of negative control was ≥ 0.8.
Vanadium concentrate resulted to be not corrosive to human skin.
This in vitro dermal study on human skin models is acceptable and satisfies the guideline requirement for a guideline study according to OECD 431 "In vitro Skin Corrosion Human Skin Model test".
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