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EC number: 300-344-4 | CAS number: 93925-42-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no guidline information, no glp information, study and protocol documented
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 994
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
- Principles of method if other than guideline:
- Four week-old male ICR mice (SPF grade, Nippon SLC) were purchased and acclimated for 1 week. Five mice each were housed in plastic cages in filtrated air-ventilated housing for small animal breeding. Animals were maintained at 24 +/- 1°C, 60 +/- % relative humidity, and a 12-h light, 12-h dark cycle, and fed pelleted rodent chow (CRF-1, Oriental Kobo) and water ad libitum. Pure TEOS (99.999%, Kojyundo Kagaku Kenkyusho) was bubbled with dry air. The TEOS vapor was diluted with filtered room air, and introduced into a 550 l stainless steel chamber with a dynamic flow rate of 30 l/min. Groups of ten mice in stainless steel wire cages were exposed to 1000 ppm TEOS for I, 2, 4 or 8 h in the acute inhalation study, or 50, 100 and 200 ppm TEOS 6 h/day, 5 days/week, for 2 or 4 weeks in the subchronic inhalation study. During exposure, animals were fed pelleted rodent chow and water ad libitum. Control mice were exposed to filtered room air using the same type of exposure chamber. The air sample was collected from the center of the chamber, and the TEOS concentration was monitored at approximately 10-rain intervals in the acute inhalation study and 20-min intervals in the subchronic inhalation study using a gas chromatograph (163, Hitachi). At the end of daily exposure, the chamber was quickly ventilated by filtrated room air at flow rate of 150 l/rain.
The behavior and external appearance of mice were checked every day, and body weight was measured before starting TEOS exposure, during the inhalation period and in the morning during the observation period. After finishing TEOS exposure, all mice in the acute inhalation study and half those in the subchronic inhalation study were observed lbr 2 weeks. The other mice in the subchronic inhalation study were killed I day after exposure. Prior to cervical dislocation, mice were anesthetized with diethylether, and blood was collected from the axillary vessels. Red blood cells (RBC), hemoglobin (Hb), hematocrit IHt) and white blood cells {WBC) were measured using an automated blood cell counter (CC- 170. Toa lyo Denshi). The differential WBC count was determined by counting 200 Wright-Giemsa stained white blood cells under a microscope. Blood urea nitrogen (BUN), serum creatinine, asparlate aminotransferase (EC 2.6. I. I, AST). and alanine aminotransferase (EC _.6.1._+ AUF) were measured using a dry chemistry analyzer (Dry Labo 80 M, Konica). The lung, liver, kidney, spleen and pancreas were removed, and fixed with 10% buffered neutral formalin. The skull was decalcified in 10% formic acid after fixation. The organ weight was measured in the subchronic inhalation study. The organs were embedded in paraffin. sectioned, and stained with hematoxylm-eosin. One dead mouse in the group exposed for 2 h was not examined istopathologicalty because of autolysis. - GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Tetraethyl orthosilicate
- EC Number:
- 201-083-8
- EC Name:
- Tetraethyl orthosilicate
- Cas Number:
- 78-10-4
- IUPAC Name:
- tetraethyl orthosilicate
- Details on test material:
- TEOS (99.999%, Kojyundo Kagaku Kenkyusho)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Remarks on MMAD:
- MMAD / GSD: n.a.
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- acute: 1, 2, 4, 8 h
repeated: 6d / 5 d, 2 or 4 wks - Frequency of treatment:
- see duration of treatment / exposure
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
acute: 1000 ppm
Basis:
analytical conc.
- Remarks:
- Doses / Concentrations:
repeated: 50, 100, 200 ppm
Basis:
analytical conc.
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, concurrent vehicle
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- other: LC50(4h)
- Effect level:
- > 1 000 ppm
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LOAEC
- Effect level:
- < 50 ppm
- Based on:
- test mat.
- Sex:
- male
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The LOAEC is lower than 50 ppm ( 0.433 mg / L)
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