Registration Dossier
Registration Dossier
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EC number: 231-106-7 | CAS number: 7439-97-6
Carcinogenicity
Administrative data
Description of key information
- NTP study rats (1993)
- NTP study mice (1993)
- human data (Barregård_1990 and Cragle_1984), see section 7.10.2
Key value for chemical safety assessment
Justification for classification or non-classification
Additional information
There was some evidence of a carcinogenic activity in male rats based on the increased incidence squamous cell papillomas of the forestomach. Marginally increased incidence of thyroid follicular adenomas and carcinomas may have been related to mercuric chloride. There was equivocal evidence of a carcinogenic activity in female rats based on two squamous cell papillomas of the forestomach.
There was equivocal evidence of a carcinogenic activity in male mice based on the occurance of two renal tubule adenomas and one renal tubule adenocarcinomas, and there was no evidence of a carcinogenic activity in female mice. The primary toxic changes occurred in kidneys.
In conclusion, the evidence for a mutagenic or carcinogenic potential of Hg in both animal (oral exposure) and epidemiological studies (occupational inhalation exposure) is equivocal, and it is so far lacking in humans at low exposure concentrations < 50 µg/g creatinine in urine. The mutagenic or carcinogenic potential of Hg seems to be related to metal induced oxidative stress and thus, if a potential is present in humans, a threshold effects is hypothetically possible.
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