Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: European Economic Community (EEC), EEC-Directive 96/54 EC, Part B.3, Acute toxicity-dermal.
GLP compliance:
yes
Limit test:
yes

Test animals

Species:
other: Wistar rats

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
other: Polyethylene glycol 400
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 1
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: None.
Gross pathology:
Effects on organs:
No toxicologically significant abnormalities were found at
macroscopic post mortem examination of the animals. Pelvic
dilation of the kidneys was noted in one male and one
female.
Other findings:
Signs of toxicity (local):
Hunched posture noted among two males and one female on days

2 and 3. Maculate or general erythema was seen on the
treated skin area of four females during the observation
period. Animals recovered from symptoms between days 4 and
12.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU