[No public or meaningful name is available]

Endpoint summary

Description of key information

Under the conditions of this study, the acute oral approximate lethal dosage (LD50) was:

male: more than 2000 mg/kg

female: more than 2000 mg/kg

Combined sexes: more than 2000 mg/kg

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

September 25 - Otober 9, 1995

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Qualifier:

no guideline available

Principles of method if other than guideline:

Testing carried out prior to OECD guidelines. The acute oral toxicity of the test substance was studied in groups fasted male and female rats of Winstar at a dosage of 2000 mg per kg. The test material was administered on Day 0. Mortality and signs of reaction to treatment were recorded during a 14-day period of observation.

GLP compliance:

not specified

Test type:

other: Single dose method

Limit test:

yes

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age: 45 day old
- Weight at study initiation: males: 202 to 221g, females: 155 to 170g.
- Fasting period before study:
- Housing: polycarbonate cages with stainless steel grid tops
- Diet: ad libitum except on the day of dosing
- Water: ad libitum
- Acclimation period:

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 25°C +/- 3°C
- Humidity (%): 50% +/-10%
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12-hour light/dark cycle per day

IN-LIFE DATES: From: To:

Route of administration:

oral: gavage

Vehicle:

not specified

Details on oral exposure:

gavage

Doses:

2000 mg/kg

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

The acute oral toxicity of p-Menthan-3,8-diol was studied in groups fasted male and female rats of Winstar at a dosage of 2000 mg per kg. The test material was administered on Day 0. Mortality and signs of reaction to treatment were recorded during a 14-day period of observation.

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

none observed

Clinical signs:

other: none obeserved

Gross pathology:

none observed

Other findings:

not specified

Interpretation of results:

GHS criteria not met

Conclusions:

Under the conditions of this study, the acute oral approximate lethal dosage (LD50) was:
male: more than 2000 mg/kg
female: more than 2000 mg/kg
Combined sexes: more than 2000 mg/kg
Therefore, the test substance can be classifed as relatively harmless.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

2 000 mg/kg bw