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EC number: 230-601-5 | CAS number: 7214-18-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin corrosion: Not corrosive based on an OECD TG 431 test.
Skin irritation: Irritating based on OECD TG 439 test.
Eye irritation: Not irritating based on an OECD TG 438 test.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin corrosion
The potential of Verdol to cause dermal corrosion was also assessed in the EpiDerm skin corrosivity test according to OECD guideline 431. 25 mg of the test item (moistened with 25 μL H2O) were applied directly atop the EpiDerm tissue. Cytotoxicity is expressed as the reduction of mitochondrial dehydrogenase activity measured by formazan production from MTT after a 3 min and 60 min exposure period and compared to those of the concurrent negative controls. The test item has no non-specific MTT-reducing or colouring potential, therefore no additional controls were necessary. The test item showed no corrosive effects. The mean relative tissue viability (% negative control) was ≥50% (96.5%) after 3 min treatment and ≥15% (67.1%) after 60 min treatment.
Skin irritation:
The skin irritant potential of Verdol was analysed using the EpiDerm™-Standard Model (EPI-200™). 25 mg of the test item was applied topically. Cytotoxicity is expressed as the reduction of mitochondrial dehydrogenase activity measured by formazan production from MTT after a 60 min exposure and 42 h post-incubation period and compared to those of the concurrent negative controls. The test item has no non-specific MTT-reducing or colouring potential, therefore no additional controls were necessary. The test item showed irritant effects. The mean relative tissue viability (% negative control) was ≤ 50% (2.9%) after 60 min treatment and 42 h post-incubation. The test item is therefore classified as “irritant”.
Eye irritation:
An Isolated Chicken Eye Test (ICET) was performed with the substance according to OECD guideline 438 and in accordance with GLP principles. Thirty mg of the substance was applied to corneas (n=3). After 10 seconds exposure time, the surface of the eyes was rinsed with physiological saline solution. Slight corneal swelling change (mean = 14.2%) was observed during the four-hour observation period on test item treated eyes. Slight cornea opacity change (severity 1 on all three eyes) was observed. No fluorescein retention change was noted on all eyes. No other morphological effect was observed. Based on the results, the endpoints Corneal swelling and Corneal opacity were assigned ICE CLASS II and the Fluorescein retention endpoint was assigned ICE CLASS I. Therefore, the substance is considered as non-irritant.
Justification for classification or non-classification
Based on the results of the available in vitro skin and eye studies, the substance need to be classified as Category 2 skin irritant and not classified for eye irritation according to EU CLP (EC 1272/2008 and its amendments).
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