Registration Dossier
Registration Dossier
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EC number: 427-820-5 | CAS number: 2701-50-0 1,2-METHYLEN-4,6-DIENACETAT
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1992
- GLP compliance:
- yes
Test material
- Reference substance name:
- 17-acetoxy-1β,2β-methanopegna-4,6-diene-3,20-dione
- EC Number:
- 427-820-5
- EC Name:
- 17-acetoxy-1β,2β-methanopegna-4,6-diene-3,20-dione
- Cas Number:
- 2701-50-0
- Molecular formula:
- C24H30O4
- IUPAC Name:
- (1S,2S,3R,5S,11R,12S,15R,16S)-15-acetyl-2,16-dimethyl-6-oxopentacyclo[9.7.0.0²,⁸.0³,⁵.0¹²,¹⁶]octadeca-7,9-dien-15-yl acetate
- Test material form:
- solid: bulk
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- physiological saline
- Controls:
- no
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 2 males/ 2 females
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
Any other information on results incl. tables
Results of the study:
| Test compound ZK 5690 | Animal number and sex | ||||||
| Location (finding) | Time-point after end of exposure | 266M | 270M | 295F | 299F | ||
| Reddening and scab formation | 30 -60 min | 0 | 0 | 0 | 0 | ||
| 24 hours | 0 | 0 | 0 | 0 | |||
| 48 hours | 0 | 0 | 0 | 0 | |||
| 72 hours | 0 | 0 | 0 | 0 | |||
| Individual mean values: | 0 | 0 | 0 | 0 | |||
| Mean value of all animals: | 0 | ||||||
| Swellings | 30 -60 min | 0 | 0 | 0 | 0 | ||
| 24 hours | 0 | 0 | 0 | 0 | |||
| 48 hours | 0 | 0 | 0 | 0 | |||
| 72 hours | 0 | 0 | 0 | 0 | |||
| Individual mean values | 0 | 0 | 0 | 0 | |||
| Mean values of all animals | 0 | ||||||
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- the test item revealed no skin irritating properties
- Executive summary:
ZK 5.690 was tolerated without any compound-related findings on the intact skin of the rabbit after single application. The irritation index according to Draize (see table 2) was 0, indicating no local irritation of ZK 5.690.
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