Registration Dossier
Registration Dossier
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EC number: 206-860-5 | CAS number: 387-45-1
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 4.4.1984
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- Richtlinie 84/449/EWG:
Richtlinie der Kommission vom 25. April 1984 zur sechsten Anpassung der Richtlinie 67/548/EWG des Rates zur Angleichung der Rechts- und Verwaltungsvorschriften
für die Einstufung, Verpackung und Kennzeichnung gefährlicher Stoffe an den technischen Fortschritt.
- Qualifier:
- according to guideline
- Guideline:
- other: "Letale Wirkung beim Zebrabärblinq Brachvdanio rerio" (LCO, LC50, LC100; 48 - 96 STUNDEN) Empfehlung des Umweltbundesamtes zur Durchführung der Prüfung nach §4 Abs.l Nr.6 der Verordnung über Anmeldeunterlagen und Prüfnachweise nach dem Chemikaliengesetz.
- Version / remarks:
- Texte 16/84, Umweltbundesamt
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-chloro-6-fluorobenzaldehyde
- EC Number:
- 206-860-5
- EC Name:
- 2-chloro-6-fluorobenzaldehyde
- Cas Number:
- 387-45-1
- Molecular formula:
- C7H4ClFO
- IUPAC Name:
- 2-chloro-6-fluorobenzaldehyde
- Test material form:
- liquid
Constituent 1
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebrabärbling (Brachydanio rerio)
- Strain: HAMILTON-BUCHANAN
- Source: West Aquarium, 3422 Bad Lauterberg
- Hatch date: 01.02.90 / 07.02.90 / 21.02.90
- Delivery date: 24.04.90 / 03.05.90 / 17.05.90
- Length at study initiation (length definition, mean, range and SD): 3 cm (2.7-3.3) S = 0.14
ACCLIMATION
- Acclimation period: 14 d
- Acclimation conditions (same as test or not): same
- Type and amount of food during acclimation: Tetra Hin, Tetra Werke, Melle
- Feeding frequency during acclimation: twice a day ad libitum
- Health during acclimation (any mortality observed): No mortality observed
Study design
- Test type:
- semi-static
- Water media type:
- other: Reconstituted water according to the composition according to ISO / DIN 7346/1 was used as the dilution water.
- Total exposure duration:
- 96 h
Test conditions
- Test temperature:
- 21.4-22.6°C
- pH:
- 7.8-8.3
- Dissolved oxygen:
- 7.3-8.8 mg/l
- Nominal and measured concentrations:
- The mean measured values were over 80% of the nominal concentration.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 22 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- >= 10 - <= 22 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 48 h
- Dose descriptor:
- LC100
- Effect conc.:
- 22 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 14.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 48 h
- Dose descriptor:
- LC0
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
