Sodium O-ethyl dithiocarbonate

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Metabolism of xanthates in man and guinea pig

Author:

Merlevede E and Peters J

Year:

1965

Bibliographic source:

Archives of the Belgian Medical Society, 23(8): 513-551

Materials and methods

Test guideline

Qualifier:

no guideline followed

GLP compliance:

not specified

Limit test:

no

Test material

Test material information

1

Reference substance name:

Sodium O-ethyl dithiocarbonate

EC Number:

205-440-9

EC Name:

Sodium O-ethyl dithiocarbonate

Cas Number:

140-90-9

Molecular formula:

C3H6OS2.Na

IUPAC Name:

sodium (ethoxymethanethioyl)sulfanide

Test material form:

solid: bulk

Details on test material:

SEX /sodium O-ethyl dithiocarbonate is produced by the reaction of an ethyl alcohol with sodium hydroxide to form alcoholate and subsequently adding carbon disulfide to form SEX/ sodium O-ethyl dithiocarbonate.
SEX /sodium O-ethyl dithiocarbonate contains Ethanol/ethyl alcohol (CAS number 64-17-5) and sodium hydroxide (CAS number 1310-73-2) which are an integral part of the substance.
Ethanol/ethyl alcohol (CAS number 64-17-5) and sodium hydroxide (CAS number 1310-73-2) are both reagents used in the manufacture of SEX /sodium O-ethyl dithiocarbonate. Therefore, Ethanol/ethyl alcohol (CAS number 64-17-5) and sodium hydroxide (CAS number 1310-73-2) need to be considered in the assessment of SEX /sodium O-ethyl dithiocarbonate.


CAS name: ethyl alcohol
EC / List name: Ethanol
IUPAC name: ethanol
EC / List no.: 200-578-6
CAS no.: 64-17-5

CAS name: sodium hydroxide
EC / List name: Sodium hydroxide
IUPAC name: sodium hydroxide
EC / List no.: 215-185-5
CAS no.: 1310-73-2

Test animals

Species:

guinea pig

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

subcutaneous

Vehicle:

unchanged (no vehicle)

Doses:

70-200 mg/kg of potassium ethyl xanthate

Control animals:

yes

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

other: elimination of CS2

Effect level:

50 - 100 mg/kg bw

Based on:

test mat.

Remarks on result:

other: A morerapid rate of elimination was seen following sub-cutaneous injection (50 and 100mg/kg) of sodium ethyl xanthate, with CS2 expiration complete after 6 h, with maximum elimination at 1 h

Clinical signs:

A morerapid rate of elimination was seen following sub-cutaneous injection (50 and 100 mg/kg) of sodium ethyl xanthate, with CS2 expiration complete after 6 h, with maximum elimination at 1 h (total recovery of CS2 was not reported).

Any other information on results incl. tables

Following sub-cutaneous injection (70-200 mg/kg) of potassium ethyl xanthate in guinea pigs, up to 7% of the dose was expired as CS2 after 8 h, with maximumelimination between 1 - 2 h in most animals. The rate of elimination was dose related,however the total percentage recovered was independent of dose. A morerapid rate of elimination was seen following sub-cutaneous injection (50 and 100 mg/kg) of sodium ethyl xanthate, with CS2 expiration complete after 6 h, with maximum elimination at 1 h (total recovery of CS2 was not reported).

Applicant's summary and conclusion

Conclusions:

Following sub-cutaneous injection (70-200 mg/kg) of potassium ethyl xanthate in guinea pigs, up to 7% of the dose was expired as CS2 after 8 h, with maximum elimination between 1 - 2 h in most animals. The rate of elimination was dose related, however the total percentage recovered was independent of dose. A more rapid rate of elimination was seen following sub-cutaneous injection (50 and 100mg/kg) of sodium ethyl xanthate, with CS2 expiration complete after 6 h, with maximum elimination at 1 h (total recovery of CS2 was not reported).