Registration Dossier
Registration Dossier
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EC number: 251-379-6 | CAS number: 33100-27-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Thirteen Cationic Ionophores: Their Acute Toxicity, Neurobehavioral and Membrane Effects
- Author:
- S. C. Gad, C. Reilly, K. Siino, F. A. Gavigan & G. Witz
- Year:
- 2 008
- Bibliographic source:
- DRUG AND CHEMICAL TOXICOLOGY, 8( 6 ) , 451-468 (1985)
Materials and methods
- Principles of method if other than guideline:
- 15-Crown-5 was applied to eyes of rabbits and then scored by the Draize procedure at 1, 2, 3, 4, 7 and 10 days post installation.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,4,10,13-pentaoxacyclopentadecane
- EC Number:
- 251-379-6
- EC Name:
- 1,4,10,13-pentaoxacyclopentadecane
- Cas Number:
- 33100-27-5
- Molecular formula:
- C10H20O5
- IUPAC Name:
- 1,4,7,10,13-pentaoxacyclopentadecane
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Amount / concentration applied:
- 0.01 mL
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Eye irritation grade
- Basis:
- mean
- Time point:
- other: 1, 2, 3, 4, 7 and 10 days
- Remarks on result:
- probability of moderate irritation
Applicant's summary and conclusion
- Conclusions:
- The test substance is considered to cause Moderate eye irritation
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