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EC number: 844-009-5 | CAS number: 167173-85-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Phototransformation in water
Administrative data
- Endpoint:
- phototransformation in water
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
- Study type:
- other: surface and solution phase photolysis
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- For surface phase photolysis, 10 µg of compound was applied to a PTFE surface and exposed in a UV chamber for various time points along with dark controls. The freeze dried mycelium (X633974) powder containing the active ingredient X642188 (UK-2A) was also evaluated for surface photolysis stability. Additionally the photostability of X642188 (UK-2A) was evaluated in solution (10 ppm in pH 4 buffer). In addition, X642188 was evaluated for hydrolytic stability under neutral (pH 7), acidic (pH 4) and basic (pH 10) conditions.
- GLP compliance:
- no
Test material
- Reference substance name:
- (3S,6S,7R,8R)-8-benzyl-3-(3-hydroxy-4-methoxypyridine-2-amido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl 2-methylpropanoate
- Cas Number:
- 167173-85-5
- Molecular formula:
- C26H30N2O9
- IUPAC Name:
- (3S,6S,7R,8R)-8-benzyl-3-(3-hydroxy-4-methoxypyridine-2-amido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl 2-methylpropanoate
Constituent 1
- Specific details on test material used for the study:
- Substance name: X642188 (UK-2A)
Purity: Not specified
Study design
- Radiolabelling:
- no
- Analytical method:
- high-performance liquid chromatography
- Light source:
- other: UV chamber
Duration of test at given test condition
- Initial conc. measured:
- 10 other: µg
- Dark controls:
- yes
Results and discussion
Dissipation half-life of parent compoundopen allclose all
- Key result
- DT50:
- 30.6 d
- Test condition:
- X642188 (UK-2A) (surface phase photolysis)
- DT50:
- 22 h
- Test condition:
- X642190 (UK-2C/2D) (surface phase photolysis)
- DT50:
- 15 h
- Test condition:
- X650872 (UK-3A) (surface phase photolysis)
- DT50:
- 10.6 d
- Test condition:
- freeze dried mycelium (X633974) powder containing the active ingredient X642188 (UK-2A) (surface photolysis stability)
- Key result
- DT50:
- 1.2 h
- Test condition:
- X642188 (UK-2A) was evaluated in solution (10 ppm in pH 4 buffer)
- Key result
- DT50:
- 5.1 h
- Test condition:
- X642188 at pH 4
- Key result
- DT50:
- 6.9 h
- Test condition:
- X642188 at pH 7
- Key result
- Test condition:
- X642188 at pH 10
- Remarks on result:
- other: hydrolysis appeared to be instantaneous. No X642188 was detectable even at the initiation of the experiment.
Applicant's summary and conclusion
- Conclusions:
- Several of the picolinamides investigated in this study have limited stability in sunlight on surfaces such that care will need to be taken to minimize its effect. More importantly however, is the hydrolytic instability of the primary candidate X642188. When diluted for application from the formulated material, the solution pH should be maintained acidic or neutral. From these studies it is apparent that X642188 has an extremely limited life-time under basic aqueous conditions. Additionally, UV screening of the application solution will also be necessary to maintain a consistent application due to the photolysis of X642188 in solution.
- Executive summary:
Several naturally derived picolinamides received from Meiji Company were evaluated for surface and solution phase photostability. For surface phase photolysis, 10 µg of compound was applied to a PTFE surface and exposed in a UV chamber for various time points along with dark controls. Samples were exposed in triplicate for each time point. Samples were removed at predetermined intervals, extracted with acetonitrile and analyzed by HPLC to determine the extent of photodegradation. Half-lives for each compound were determined as follows: X642188 (UK-2A) 30.6 days, X642190 (UK-2C/2D) 22 hours, and X650872 (UK-3A) 15 hours. The freeze dried mycelium (X633974) powder containing the active ingredient X642188 (UK-2A) was also evaluated for surface photolysis stability. The half-life for the mixture was slightly faster than the pure isolate at 10.6 days due to the differing application technique used to apply the test solution to the PTFE disks.
Additionally the photostability of X642188 (UK-2A) was evaluated in solution (10 ppm in pH 4 buffer). Photolysis was extremely rapid in solution with an estimated half-life of 1.2 hours. In addition, X642188 was evaluated for hydrolytic stability under neutral (pH 7), acidic (pH 4) and basic (pH 10) conditions. Hydrolysis appeared to be base catalyzed. At pH 4 X642188 was relatively stable with a half life of 5.1 hours. At pH 7 the half life was determined to be 6.9 hours.
Under basic pH conditions however, hydrolysis appeared to be instantaneous. No X642188 was detectable even at the initiation of the experiment. The hydrolytic stability of the mycelium powder X633974 was evaluated as well at pH 4, 7 and 10. The half-lives for the active ingredient X642188 in the mycelium powder were somewhat longer than seen for the pure material at 11 and 16 hours for pH 4 and 7, respectively. As with the pure material at pH 10, the half-life could not be determined due to the rapid nature of the hydrolysis.
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