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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish life cycle toxicity
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- Please refer to Read Across Statement attached in Section 13
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 22 mo
- Dose descriptor:
- other: MATC
- Remarks:
- hard water (330 mg CaCO3/L)
- Effect conc.:
- > 4.27 - < 8.53 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Remarks:
- converted to target substance
- Basis for effect:
- mortality
- Duration:
- 22 mo
- Dose descriptor:
- other: MATC
- Remarks:
- soft water (25 mg CaCO3/L)
- Effect conc.:
- > 1.87 - < 3.47 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Remarks:
- converted to target substance
- Basis for effect:
- mortality
- Conclusions:
- The chronic toxicity of zinc to rainbow trout decreases as water hardness increases. The MATC obtained in hard water is with 320 - 640 µg Zn/L approximately two-and-one-half times the MATC obtained in soft water (140 - 260 µg Zn/L).
This result is also relevant for the target substance, which contains 7.5 % zinc ions. Accounting to the Zn content of 7.5%, this corresponds to a MATC obtained in hard water of 4.27 - 8.53 mg/L and a MATC obtained in soft water of 1.87 - 3.47 mg/L. - Executive summary:
The chronic toxicity of zinc to rainbow trout decreases as water hardness increases. The MATC obtained in hard water is with 320 - 640 µg Zn/L approximately two-and-one-half times the MATC obtained in soft water (140 - 260 µg Zn/L).
The target substance contains 7.5 % zinc ions.
Accounting to the Zn content of 7.5%, this corresponds to a MATC obtained in hard water of 4.27 - 8.53 mg/L and a MATC obtained in soft water of 1.87 - 3.47 mg/L.
- Endpoint:
- fish, juvenile growth test
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- Please refer to Read Across Statement attached in Section 13
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 30 d
- Dose descriptor:
- LC50
- Remarks:
- pH 7.76, DOC 22.9 mg/L, Ca 32 mg/L
- Effect conc.:
- 26.27 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Remarks:
- converted to target substance
- Basis for effect:
- mortality
- Duration:
- 30 d
- Dose descriptor:
- LC50
- Remarks:
- pH 7.08, DOC 2.84 mg/L, Ca 8.05 mg/L
- Effect conc.:
- 4.49 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Remarks:
- converted to target substance
- Basis for effect:
- mortality
- Key result
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Remarks:
- pH 7.76, DOC 22.9 mg/L, Ca 32 mg/L
- Effect conc.:
- 10.28 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Remarks:
- converted to target substance
- Basis for effect:
- mortality
- Key result
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Remarks:
- pH 7.08, DOC 2.84 mg/L, Ca 8.05 mg/L
- Effect conc.:
- 2.65 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Remarks:
- converted to target substance
- Basis for effect:
- mortality
- Conclusions:
- Chronic zinc toxicity (expressed as 50 % lethal concentrations [LC50]) varied up to 6-fold for the O. mykiss (30 -d LC50 between 0.337 and 1.970 mg Zn/L). The 30-d NOECs ranged from 0.199 to 0.771 mg Zn/L.
This result is also relevant for the target substance, which contains 7.5 % zinc ions. Accounting to the Zn content of 7.5 %, this corresponds to a 30 d LC50 ranging from 4.49 to 26.27 mg/L, the NOEC (30 d) ranging from 2.65 to 10.28 mg/L for O. mykiss. - Executive summary:
Chronic zinc toxicity (expressed as 50 % lethal concentrations [LC50]) varied up to 6-fold for the O. mykiss (30 -d LC50 between 0.337 and 1.970 mg Zn/L). The 30-d NOECs ranged from 0.199 to 0.771 mg Zn/L.
This result is also relevant for the target substance, which contains 7.5 % zinc ions. Accounting to the Zn content of 7.5 %, this corresponds to a 30 d LC50 ranging from 4.49 to 26.27 mg/L, the NOEC (30 d) ranging from 2.65 to 10.28 mg/L for O. mykiss.
Referenceopen allclose all
The target substance contains 7.5 % Zn ions. Therefore, the hazard value for Zn ion is converted to the target substance considering a Zn content of 7.5 %.
MATC soft water, lower limit (Zn ion) = 0.14 mg/L
MATC soft water, lower limit (Target substance) = 0.14/0.075 = 1.87 mg/L
MATC soft water, upper limit (Zn ion) = 0.26 mg/L
MATC soft water, upper limit (Target substance) = 0.26/0.075 = 3.47 mg/L
MATC hard water, lower limit (Zn ion) = 0.32 mg/L
MATC hard water, lower limit (Target substance) = 0.32/0.075 = 4.27 mg/L
MATC hard water, upper limit (Zn ion) = 0.64 mg/L
MATC hard water, upper limit (Target substance) = 0.64/0.075 = 8.53 mg/L
The target substance contains 7.5 % Zn ions. Therefore, the hazard value for Zn ion is converted to the target substance considering a Zn content of 7.5 %.
LC50 pH 7.76 (Zn ion) = 1.97 mg/L
LC50 pH 7.76 (targte substance) = 1.97/0.075 = 26.27 mg/L
LC50 pH 7.08 (Zn ion) = 0.337 mg/L
LC50 pH 7.08 (target substance) = 0.337/0.075 = 4.49 mg/L
NOEC pH 7.76 (Zn ion) = 0.771 mg/L
NOEC pH 7.76 (target substance) = 0.771/0.075 = 10.28 mg/L
NOEC pH 7.08 (Zn ion) = 0.199 mg/L
NOEC pH 7.08 (target substance) = 0.199/0.075 = 2.65 mg/L
Description of key information
Read-Across: WoE, Zn ion, O. mykiss, 30 d LC50: 4.49 to 26.27 mg/L; NOEC (30 d): 2.65 to 10.28 mg/L (converted to the target substance taking into account the Zn content of 7.5 %)
Read-Across: WoE, Zn ion, O. mykiss, MATC obtained in hard water of 4.27 - 8.53 mg/L and a MATC obtained in soft water of 1.87 - 3.47 mg/L (converted to the target substance taking into account the Zn content of 7.5 %)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- NOEC
- Effect concentration:
- 2.65 mg/L
Additional information
Read-across - Zn ion
De Schamphelaere et al., 2005
Zinc toxicity to O. mykiss was evaluated in a series of experiments with spiked natural surface waters. The eight selected freshwater samples had varying levels of bioavailability modifying parameters: pH (5.7 – 8.4), dissolved organic carbon (DOC, 2.48 – 22.9 mg/L), Ca (1.5 – 80 mg/L), Mg (0.79 – 18 mg/L), and Na (3.8 – 120 mg/L). Chronic zinc toxicity (expressed as 50 % lethal concentrations [LC50]) varied up to 6-fold for the O. mykiss (30-d LC50 between 0.337 and 1.970 mg Zn/L). The 30-d NOECs ranged from 0.199 to 0.771 mg Zn/L.
This result is also relevant for the target substance, which contains 7.5 % zinc ions. Accounting to the Zn content of 7.5 %, this corresponds to a LC50 (30 d) ranging from 4.49 to 26.27 mg/L and a NOEC (30 d) ranging from 2.65 to 10.28 mg/L for O. mykiss
Sinley et al., 2005
The chronic toxicity of zinc to rainbow trout (O. mykiss) decreases as water hardness increases. The MATC obtained in hard water is with 320 - 640 µg Zn/L approximately two-and-one-half times the MATC obtained in soft water (140 - 260 µg Zn/L).
This result is also relevant for the target substance, which contains 7.5 % zinc ions. Accounting to the Zn content of 7.5%, this corresponds to a MATC obtained in hard water of 4.27 - 8 .53 mg/L and a MATC obtained in soft water of 1.87 - 3.47 mg/L.
Conclusion
The study conducted by De Schamphelaere et al., 2005 is regarded as the most reliable. The study using zinc as test item is conducted according to OECD 215 and is well documented. On the contrary, Sinley et al (1974) using zinc sulphate as test item and the study is not in accordance with an OECD Guideline. Addtionally only MATC ("maximal acceptable toxicant concentration") values, but no NOECs are reported. MATC values would need to be recalculated to NOECs. For both studies the GLP compliance is not specified.
Taking all information into account the NOEC as obtained by De Schamphelaere et al., 2005 is set as key value for the chemical safety assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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