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Diss Factsheets
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EC number: 203-569-5 | CAS number: 108-29-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not available, publication received 1945-05-31
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not available, publication received 1945-05-31
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: The purpose of this investigation was to determine the immediate toxicity of the test item by oral administration and its effects upon respiration and blood pressure.
- Short description of test conditions: Rabbits were treated with different volumes of the test item by gavage. No details about sex, environmental conditions or time schedule of the experiment are given.
- Parameters analysed / observed: Clinical signs, blood pressure and mortality - GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Specific details on test material used for the study:
- No details given.
- Species:
- rabbit
- Strain:
- other: Albino rabbits
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Albino rabbits were purchased from a local breeder
- Acclimation period: About 2 weeks
IN-LIFE DATES: At least 6 days - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED:
7 mL/kg bw - Doses:
- 0.94, 1.4, 2.1, 3.2, 4.7, 7.0 mL/kg bw
- No. of animals per sex per dose:
- 10 animals per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: At least 6 days
- Necropsy of survivors performed: No
- Clinical signs: Locomotor system, state of consciousness, respiration
- Other examinations: Blood pressure was recorded by means of a kymograph - Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 606 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Effect level was converted from 2.48 mL/kg bw to 2606 mg/kg bw
- Mortality:
- 0% mortality at 0.94 mL/kg bw, 20% mortality at 1.4 mL/kg bw (survival time 14 hours and 6 days), 30% mortality at 2.1 mL/kg bw (survival time 10 hours to 2 days), 60% mortality at 3.2 mL/kg bw (survival time 8 hours to 3 days), 100% mortality at 4.7 mL/kg bw (survival time 5 hours to 5 days), 100% mortality at 7.0 mL/kg bw (survival time 3-12 hours)
- Clinical signs:
- other: Clinical signs were marked muscular weakness, mild anesthesia, increase in the rate of respiration, followed by dyspnea and occasionally by mild asphyxial convulsions. Death resulted from combined effects of circulatory and respiratory failure.
- Gross pathology:
- No information given
- Other findings:
- No information given
- Interpretation of results:
- GHS criteria not met
Data source
Reference
- Reference Type:
- publication
- Title:
- Observations on the effects of gamma-valerolactone upon experimental animals
- Author:
- Deichmann WM. B., Hirose R., Witherup S.
- Year:
- 1 945
- Bibliographic source:
- Journal of industrial hygiene and toxicology, 27: No. 9
- Report date:
- 1945
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: The purpose of this investigation was to determine the effects resulting from its application upon the skin.
- Short description of test conditions: The test substance was applied to the shaved belly of rabbits for 2 hours, the procedure was repeated on several days. No details about sex, environmental and treatment are given.
- Parameters analysed / observed: Local and systemic illness, body weights - GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- γ-valerolactone
- EC Number:
- 203-569-5
- EC Name:
- γ-valerolactone
- Cas Number:
- 108-29-2
- Molecular formula:
- C5H8O2
- IUPAC Name:
- 5-methyloxolan-2-one
Constituent 1
- Specific details on test material used for the study:
- No information available.
Test animals
- Species:
- rabbit
- Strain:
- other: Albino rabbits
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Albino rabbits were purchased from a local breeder
- Acclimation period: About 2 weeks
IN-LIFE DATES: From day 0 to day 45
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- REMOVAL OF TEST SUBSTANCE
- Washing: The test item was washed off the skin with soap and water
- Time after start of exposure: 2 hours
TEST MATERIAL
- Amount applied: 2 mL/kg bw
- Constant volume or concentration used: No
- For solids, paste formed: No - Duration of exposure:
- 2 hours per exposure, exposure for 33 days over a period of 45 days
- Doses:
- 2 mL/kg bw
- No. of animals per sex per dose:
- 6 animals per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: Animals were exposed and observed over a period of 45 days.
- Frequency of weighing: At the beginning and end of the exposure period
- Necropsy of survivors performed: No
- Examinations performed: Clinical signs, body weight - Statistics:
- No statistics performed
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 102 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Remarks:
- Effect level was converted from 2 mL/kg bw to 2102 mg/kg bw
- Mortality:
- No mortality occured
- Clinical signs:
- other: None of the animals displayed signs of local or systemic illness. The compound did not produce irritation or damage to the skin of these animals.
- Gross pathology:
- No gross pathology was performed.
- Other findings:
- No other findings were observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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