Palmitoyl chloride

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

testing of saturated vapour concentration

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1970

Report date:

1970

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

(inhalation hazard test as in the annex of the guideline)

Deviations:

no

GLP compliance:

no

Test type:

other: inhalation risk test

Test material

Test material information

Constituent 1

Reference substance name:

Palmitoyl chloride

EC Number:

203-996-7

EC Name:

Palmitoyl chloride

Cas Number:

112-67-4

Molecular formula:

C16H31ClO

IUPAC Name:

hexadecanoyl chloride

Details on test material:

- Name of test material (as cited in study report): Palmitinsaeurechlorid (=Palmitoyl chloride)
- Analytical purity: 98% (analytical report: ZAX96L00731, Jan. 1997)
- Lot/batch No.: Vers. 98
- Lot/batch No.: Vers. 62/V
- Storage condition of test material: room temperature, sensitive to moisture

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Mean weight at study initiation: males 186 g; females 150 g
no further details given

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

Atmosphere was generated by bubbling 200 l/h dry air (no CO2) through the liquid substance column (volume ca. 50 ml) of about 5 cm above a fritted glass disc in a glass cylinder. The glass cylinder was heated in a water bath. Temperature in the exposure chamber was 20°C. Concentration was stated in the raw data to be 0.37 mg/L (= 32.9 ppm).
The vapour saturation treshold is calculated to be approx. 0.0014 mg/L (at 25°C).

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

0.37 mg/L (32.9 ppm) as mean of two trials with 0.363 and 0,375 mg/L, respectively

No. of animals per sex per dose:

6 (3 animals/sex in two trials)

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Weighing was performed at the start and at the end of the study. Observation was several times at the day of exposure and following presumably daily except on weekends and holidays.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Statistics:

none

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

0.37 mg/L air (nominal)

Exp. duration:

8 h

Remarks on result:

other: No mortality observed within 8 h

Mortality:

No mortality observed

Clinical signs:

other: Severe irritations of the mucosa.

Body weight:

Mean body weight after 7 d
males 220 g (+34g); females 171 g (+21 g)
Body weight development was positive

Gross pathology:

Nothing abnormal found