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Diss Factsheets
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EC number: 220-864-4 | CAS number: 2921-88-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Specific details on test material used for the study:
- Substance ID: TSN100227
Purity: 99.8% - Key result
- Water solubility:
- 0.001 g/L
- Temp.:
- 20 °C
- pH:
- >= 6.7 - <= 6.9
- Details on results:
- The solubility of the test substance at the approximately 25 mL/hr collection rate was 1.176 (± 0.030) x 10-3 g/L, and the approximately 12.5 mL/hr was 0.924 (± 0.062) x 10-3 g/L. The relative difference between each replicate solubility value at each flow rate was less than 30% for both collection flow rates, confirming the solubility values reflected equilibrium of saturated solutions. Also, since the average solubility of the test substance in water at the 25 mL/hr and 12.5 mL/hr collection rates was within 30% of the overall mean, no flow rate solubility bias was observed.
- Conclusions:
- Water solubility (20°C): 1.05E-3 g/L
- Executive summary:
The water solubility of the test substance in unbuffered water was determined at 20 ± 0.5 °C using the elution column method according to the guidelines OECD 105 and EPA OPPTS 830.7840. Saturated aqueous samples were developed by pumping water at approximately 25 mL/hr and 12.5 mL/hr over the test substance adsorbed onto an inert support. Replicate samples were assayed and an average concentration was determined for each flow rate. The two solubility values were averaged, and the solubility value for each flow rate was within 30% of the average.
The initial pH of the unbuffered water was 6.9 and 7.0 for the two sample collection flow rates. Consecutive fractions were collected and assayed at each flow rate, and the pH of the fractions immediately bracketing the consecutive fractions was determined at each flow rate (pH 6.8 ± 0.1). An external calibration curve was prepared by analyzing standard solutions of test substance, and the concentrations of the samples were determined from the calibration curve. The initial pH of the unbuffered water was pH 6.9 and pH 6.8 for the two sample collection flow rates. The solubility of the test substance at the approximately 25 mL/hr collection rate was 1.176 (± 0.030) x 10-3 g/L, and the approximately 12.5 mL/hr was 0.924 (± 0.062) x 10-3 g/L. The average solubility of the test substance in unbuffered water at 20°C was determined to be 1.050 x 10-3 (± 0.140 X 10-3) g/L.
Reference
Description of key information
OECD 105; EPA OPPTS 830.7840
Key value for chemical safety assessment
- Water solubility:
- 0.001 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.