Registration Dossier
Registration Dossier
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EC number: 948-256-0 | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Resinoid of Boswellia serrata (Burseraceae) obtained from exudate by hexane extraction
- EC Number:
- 948-256-0
- IUPAC Name:
- Resinoid of Boswellia serrata (Burseraceae) obtained from exudate by hexane extraction
Constituent 1
- Specific details on test material used for the study:
- Name: Resinoid of Boswellia serrata (Burseraceae) obtained from exudate by hexane extraction
Batch number: 06/1234
EC number: 948-256-0
Appearance: Amber crystal
Purity: 100% UVCB
Expiry date: 29 February 2020
Storage conditions: Refrigerated (2-8°C), protected from light and humidity (stored in a tightly closed container)
Safety precautions: Routine safety precautions (gloves, goggles, face mask, lab coat) for unknown materials were applied to ensure personnel health and safety.
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficientopen allclose all
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 1 - < 6.5
- Temp.:
- 25 °C
- Remarks on result:
- other: peaks 3 to 12
- Key result
- Type:
- log Pow
- Partition coefficient:
- < 1
- Temp.:
- 25 °C
- Remarks on result:
- other: peak 2
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 6.5
- Temp.:
- 25 °C
- Remarks on result:
- other: peaks 13 to 19
- Details on results:
- The test item showed 19 significant visible peaks. The estimated log Pow values are varying in range <1.0 – 6.5<.
The estimated log Pow values are in the following:
• There is a peak where the log Pow value was not interpretable due to the observed retention time (
• There are some peaks where the estimated log Pow values are >6.5.
Applicant's summary and conclusion
- Executive summary:
In the course of this study the partition coefficient (log Pow) of Resinoid of Boswellia serrata (Burseraceae) obtained from exudate by hexane extraction was estimated using high performance liquid chromatography.
The test item showed 19 significant visible peaks. The estimated log Pow values are varying in range <1.0 – 6.5<.
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