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Diss Factsheets
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EC number: 701-337-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Immunotoxicity
Administrative data
Description of key information
Oral immunotoxicity study, mice (not according to OECD guidelines):
Key value for chemical safety assessment
Effect on immunotoxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 5 000 mg/kg bw/day
Additional information
Mice were exposed by oral gavage to RDP for 28 days to study immunotoxicity. Dose levels were 500, 1500 and 5000 mg/kg bw/day. Controls were sham exposed and positive controls were included. Several immunological related organs, cells and parameters were studied.
No significant differences in absolute or relative spleen or thymus weights were found. No effect of test substance was noted in spleen or thymus cellularity or peritoneal cell numbers or viability. Histopathology of thymus, spleen, mandibular, mediastinal and mesenteric lymph nodes showed no test substance-related changes. No change in splenic natural killer cell activity was observed. No change in splenic antibody forming cell function was found. No difference in peritoneal macrophage phagocytic activity was observed. No change in susceptibility to Listeria monocytogenes infection was observed. The positive control mice showed significant signs of immunotoxicity/mortality (decreased AFC and mean survival time, increased mortality).
Under the conditions of this study, Fyrolflex RDP produced no adverse effects on immunologic function in mice. A NOAEL for immunotoxicity of 5000 mg/kg bw/day could therefore be established.
Justification for classification or non-classification
Based on the available information, RDP does not have to be classified according to the criteria laid down in Annex VI of the EEC Council Directive 67/548/EEC (amended by Directive 83/467/EEC), and outlined in Annex I of 1272/2008/EC (CLP/EU-GHS).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.