Registration Dossier
Registration Dossier
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EC number: 434-080-7 | CAS number: 208343-47-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Functional groups relevant for hydrolysis
The substance contains ether bonds wich are generally stable with regard to pH-dependent hydrolysis at pH values present in the gastrointestinal tract. Hydrolysis of the substance is, therefore not expected.
Functional groups relevant for elimination
The route of excretion is assumed to be via the biles using the glucuronic acid-conjugate pathway; glucuronic acid conjugates are most likely formed with the phenolic -OH groups. It is considered rather unlikely, that water-soluble metabolites would be formed by oxidation along the sidechain and sulfation on the phenolic -OH. Thus, the absence of metabolism and subsequent excretion of unchanged material is also possible.
Indication of uptake
In the intestines, due to its very low solubility in water and the large molecular weight only a small amount of the article is expected to be absorbed. Almost the entire ingested test item is expected to pass the intestines unchanged and to be excreted directly via faeces.
Evaluation of the bioaccumulation potential
A bioaccumulation of the test substance is considered unlikely, due to the fact that the test item is most likely not absorbed from the gastrointestinal system.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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