Registration Dossier
Registration Dossier
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EC number: 948-085-1 | CAS number: -
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 26.03.2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Reference
- Title:
- Prediction of EC50 (Activated Sludge, Respiration Inhibition Test) for copper gluconate+copper sulphate+sodium sulphate
- Year:
- 2 019
- Bibliographic source:
- QSAR Toolbox 3.4.0.17
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSAR R6
Test material
- Reference substance name:
- Copper di-D-gluconate
- EC Number:
- 208-408-2
- EC Name:
- Copper di-D-gluconate
- Cas Number:
- 527-09-3
- Molecular formula:
- C12H22CuO14
- IUPAC Name:
- copper(2+) bis(2,3,4,5,6-pentahydroxyhexanoate)
- Reference substance name:
- Sodium sulphate
- EC Number:
- 231-820-9
- EC Name:
- Sodium sulphate
- Cas Number:
- 7757-82-6
- Molecular formula:
- H2O4S.2Na
- IUPAC Name:
- disodium sulfate
- Reference substance name:
- Copper sulphate
- EC Number:
- 231-847-6
- EC Name:
- Copper sulphate
- Cas Number:
- 7758-98-7
- Molecular formula:
- CuSO4
- IUPAC Name:
- copper(2+) ion sulfate
- Test material form:
- liquid
- Remarks:
- Bluish liquid
Constituent 1
Constituent 2
Constituent 3
- Specific details on test material used for the study:
- SMILES: O=S(=O)(O{-}.[Na]{+})O{-}.[Na]{+}_O=S1(=O)O{-}.[Cu]{2+}.O{-}1_OCC{P-}(O)C{P-}(O)C{P+}(O)C{P-}(O)C(=O)O{-}.[Cu]{2+}.O{-}C(=O)C{P-}(O)C{P+}(O)C{P-}(O)C{P-}(O)CO
Results and discussion
Effect concentrations
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1 770 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Remarks on result:
- other: QSAR predicted value
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The value obtained for the Activated Sludge of the prediction was 1.77E+03 mg/L. EC50 (3h)
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