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EC number: 500-013-6 | CAS number: 9004-78-8 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- other: expert assessment
- Adequacy of study:
- key study
- Study period:
- 2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Assessment based on the properties of the indvidiual constituents of the substance
Data source
Reference
- Reference Type:
- other: expert assessment
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- An assessment was conducted based on the properties of the indvidiual constituents of the substance.
- GLP compliance:
- no
Test material
- Reference substance name:
- Phenol, ethoxylated
- EC Number:
- 500-013-6
- EC Name:
- Phenol, ethoxylated
- Cas Number:
- 9004-78-8
- Molecular formula:
- not applicable - the substance is a multiconstituent substance
- IUPAC Name:
- 2-phenoxyethan-1-ol
- Test material form:
- liquid
Constituent 1
Results and discussion
In vitro
Results
- Remarks on result:
- other: An assessment was conducted based on the properties of the indvidiual constituents of the substance. It concluded that the substance shall be classified as Eye Dam. 1; H318.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- An assessment was conducted based on the properties of the indvidiual constituents of the substance. It concluded that the substance shall be classified as Eye Dam. 1; H318.
- Executive summary:
The capacity of Phenol, ethoxylated to be irritant to the eye was assessed based on the available information on its constituents.
2-phenoxyethanol is classified as Eye Irrit 2; H319 and 2-(2-phenoxyethoxy)ethanol as Eye Dam. 1; H318 based on available experimental data.
Considering the structural similarities between the constituents of Phenol, ethoxylated and in the absence of experimental data on the substance, 2-[2-(2-phenoxyethoxy)ethoxy]ethanol can be expected to be damaging to the eye.
It is concluded that Phenol, ethoxylated does not meet the criteria for classification as irritant to the eye according to the CLP Regulation. However, it is proposed to conduct testing on the substance in order to confirm the conclusion.
In accordance with the CLP Regulation, since the concentration of constituents of Phenol, ethoxylated classified as damaging to the eye is above 3%, the substance shall be classified as Eye Dam. 1; H318.
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