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EC number: 907-489-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10/05/2017-16/11/2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- Activated sludge, municipal wastewater treatment plant, Breisgauer Bucht, 30 mg dry solids per litre. The treatment plant clarifies predominantly domestic wastewater and has a capacity of 600.000 inhabitant equivalents. Sampling date of activated sludge was on 7 August 2017. The dry solid content of the activated sludge was 3.9 g/L. It was determined by weight measurements after drying at 105°C for 4 hours (mean of triplicate measurements). The activated sludge was washed twice with tap water by settling the sludge, decanting the supernatant and re-suspending the sludge.
- Duration of test (contact time):
- 28 d
- Initial conc.:
- > 10 - < 20 mg/L
- Based on:
- TOC
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- In total three reactors containing the test item, three reactors containing only inoculum (blank), three reactors containing the reference compound and one reactor containing test item and
reference compound (toxicity control) were set up.
- Test item:
The test item was pipetted directly into the test vessels. 50.6 μL were pipetted into the test vessels, corresponding to a test concentration of 20.0 mg/L organic carbon.
- Reference substance:
A stock solution of 10.0 g/L sodium benzoate in water was prepared. 5.15 mL of this stock solution were added into the reference vessels corresponding to a concentration of mg/L organic carbon.
- Toxicity control:
50.6 μL of the test item and 5.15 mL of the reference stock solution (10 g/L) were added to the toxicity control vessel corresponding to a concentration of 40.0 mg/L organic carbon. - Reference substance:
- benzoic acid, sodium salt
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 76.5
- Sampling time:
- 28 d
- Remarks on result:
- other: mean of the 3 flasks
- Details on results:
- The degradation extent of the test item at the end of the test was 76.5% (28 d after acidification, mean of three replicates. A mean degradation of >60% was measured on day 7 and was thus reached within a 10d-window.
The degradation extent in the toxicity control was 78.2% within 14 days, the test substance had no inhibitory effect on the inoculum. - Results with reference substance:
- The reference compound sodium benzoate reached the pass level for ready biodegradability within 3 days
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The test item reached the criteria for ready biodegradability (60% of ThCO2 within a 10-d window).
- Executive summary:
A CO2 Evolution Test according to OECD 301 B (July 1992) was conducted in order to investigate the ready biodegradability of Reaction mass of diethyl adipate and diethyl glutarate and diethyl succinate. The degradation extent of the test item at the end of the test was 76.5% after 28 days (after acidification, mean of three replicates). A mean degradation of >60% was measured on day 7 and was thus reached within a 10d-window. Therefore the test item reached the criteria for ready biodegradability (60% of ThCO2 within a 10-dwindow).
Reference
Table 1: Ultimate biodegradation after x days (% of ThCO2)
reactor |
day |
0 |
3 |
7 |
10 |
14 |
21 |
28 |
29 |
|
|
|
|
|
|
|
|
|
|
7 8 9 |
Test flasks |
0 |
48.7 |
71.8 |
76.0 |
83.6 |
84.0 |
88.0 |
88.5 |
0 |
38.2 |
64.0 |
69.1 |
74.3 |
75.7 |
72.4 |
70.5 |
||
0 |
42.0 |
68.8 |
67.5 |
68.8 |
70.3 |
69.4 |
70.6 |
||
4 5 6 |
reference flasks |
0 |
65.8 |
80.3 |
86.0 |
88.0 |
96.4 |
101.0 |
101.9 |
0 |
58.4 |
76.7 |
77.6 |
77.5 |
84.6 |
89.2 |
88.9 |
||
0 |
66.2 |
73.3 |
78.6 |
77.8 |
80.2 |
77.7 |
76.2 |
||
10 |
Toxicity control Testitem Reference item |
0 |
36.6 |
64.6 |
75.1 |
78.2 |
85.1 |
84.7 |
85.6 |
Description of key information
The ready biodegradability of the test item was investigated in a GLP-compliant ready biodegradability screening study performed in accordance with OECD Guideline No. 301B. The degradation of the test item at the end of the test was 76.5% (based on ThCO2) after 28 days. The test item reached the criteria for ready biodegradability according to the OECD criteria (≥ 60% ThOD and fulfilment of the 10-d window). The test item is thus considered "readily biodegradable".
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
The ready biodegradability of the test item was investigated in one GLP-compliant study performed in accordance with OECD Guideline No. 301B, without deviations. The study is considered as reliable (Klimisch 1) and is selected as a key study for the endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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