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EC number: 500-046-6 | CAS number: 26183-52-8 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 2, 1995 - July 27, 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well conducted study performed according to established methodology
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: EPA Guideline No. 81-5
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Decan-1-ol, ethoxylated
- Cas Number:
- 26183-52-8
- Molecular formula:
- not applicable
- IUPAC Name:
- Decan-1-ol, ethoxylated
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ray Nichols Rabbitry; Lumberton, Texas
- Age at study initiation: Young adult
- Weight at study initiation: Males (2.050-2.900 kg); Females (2.625-3.200 kg)
- Housing: 1 per cage (Suspended, wire bottom, stainless steel)
- Diet (e.g. ad libitum): Purina Rabbit Chow; presented in measured amounts
- Water (e.g. ad libitum): Municipal water supply, available ad libitum from automatic
water system
- Acclimation period: At least five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 72° ± 5°F
- Humidity (%): 30 - 80 %
- Air changes (per hr): 10-12
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL of the undiluted test material
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 h
- Number of animals:
- 6 (3 m / 3 f)
- Details on study design:
- The study was conducted on six New Zealand White rabbits, 3 male and 3 female, to determine the skin irritation potential of the test material. The animals were individually housed, equilibrated in the laboratory, and released from quarantine prior to testing. Normal growth, appearance, and behavior during the equilibration period were factors used to select healthy animals for testing.
Each animal was prepared on the day prior to treatment by clipping the dorsal area of the trunk free of hair to expose an area at least 8 x 8 cm. Only those animals with exposure areas free of pre-existing skin irritation or defects were selected for testing. A single intact exposure site was selected as the test site while the contralateral intact site served as a control site.
On Day 0, 0.5 mL of the undiluted test material was applied to each test site and covered with a surgical gauze patch measuring 2.5 x 2.5 cm and two single layers thick. Each patch was secured in place with a strip of non-irritating adhesive tape. The entire trunk of each animal was loosely wrapped with a semi-permeable dressing (orthopedic stockinette) and secured on both edges with . strips of tape to retard evaporation of volatile substances and to prevent possible ingestion of the test material..
After four hours, the patches and wrappings were removed. The test sites were gently washed with room temperature tap water and a clean wet cloth to remove as much residual test material as possible.
The test sites were observed for erythema and edema formation, and any other dermal defects or irritation at 1/2, 24, 48 and 72 hours after washing.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.17
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Very slight erythema was present at each observation through 24 hours in three animals. Edema was not observed at any time throughout the study. No other signs of irritation were observed during the study.
- Other effects:
- none
Any other information on results incl. tables
Erythema Edema
Animal number 1/2 h 24 h 48 h 72 h 1/2 h 24 h 48 h 72 h
1 (m) 1 1 0 0 0 0 0 0
2 (m) 1 0 0 0 0 0 0 0
3 (m) 1 1 0 0 0 0 0 0
4 (f) 1 0 0 0 0 0 0 0
5 (f) 1 1 0 0 0 0 0 0
6 (f) 1 0 0 0 0 0 0 0
m = male; f = female
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Reported skin irritation results for the test animals do not meet the criteria for irritant or mild irritant under GHS.
- Executive summary:
The study was conducted on six New Zealand White rabbits, 3 male and 3 female, to determine the skin irritation potential of the test material. The animals were individually housed, equilibrated in the laboratory, and released from quarantine prior to testing. Normal growth, appearance, and behavior during the equilibration period were factors used to select healthy animals for testing.
Each animal was prepared on the day prior to treatment by clipping the dorsal area of the trunk free of hair to expose an area at least 8 x 8 cm. Only those animals with exposure areas free of pre-existing skin irritation or defects were selected for testing. A single intact exposure site was selected as the test site while the contralateral intact site served as a control site.
On Day 0, 0.5 mL of the undiluted test material was applied to each test site and covered with a surgical gauze patch measuring 2.5 x 2.5 cm and two single layers thick. Each patch was secured in place with a strip of non-irritating adhesive tape. The entire trunk of each animal was loosely wrapped with a semi-permeable dressing (orthopedic stockinette) and secured on both edges with . strips of tape to retard evaporation of volatile substances and to prevent possible ingestion of the test material..
After four hours, the patches and wrappings were removed. The test sites were gently washed with room temperature tap water and a clean wet cloth to remove as much residual test material as possible.
The test sites were observed for erythema and edema formation, and any other dermal defects or irritation at 1/2, 24, 48 and 72 hours after washing.
Very slight erythema was present at each observation through 24 hours in three animals. Edema was not observed at any time throughout the study.
Reported skin irritation results for the test animals do not meet the criteria for irritant or mild irritant under GHS.
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