Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-906-8 | CAS number: 75-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- 2,2-Dimethylbutane - Boundary Composition
- Type of composition:
- boundary composition of the substance
- State / form:
- liquid
- Reference substance:
- 2,2-Dimethylbutane - Boundary Composition
- PBT status:
- the substance is not PBT / vPvB
- Justification:
PBT/vPvB criteria and justification
Persistence (P) Assessment: A substance is not considered to be persistent if it can be demonstrated that it has potential to degrade (via photolysis, hydrolysis and/or biodegradation)
There is no key data available for 2,2-dimethylbutane. Key data is available for Hydrocarbons, C6, isoalkanes, <5% n-hexane which have been used to read across to 2,2-dimethylbutane.
An OECD 301F Manometric Respirometry test was conducted using C6-C7, n-alkanes, isoalkanes, cyclics C6 aliphatics (Shell, 1997a). The test substance was 98% degraded at the end of 28 days, and 83% degraded at the end of the 10 -day window, and was determined to be readily biodegradable. Therefore, 2,2-dimethylbutane is also assumed to be readily biodegradable.
Therefore, 2,2-dimethylbutane does not meet the Persistent (P) or very Persistent (vP) criteria.
Bioaccumulation (B) Assessment: If the substance has a log Kow lower than 4.5 and no specific mechanism of uptake apart from hydrophobic partitioning is known and the possibility for accumulation in other food chains than the aquatic food chain can be ruled out, then the substance can be considered as not B and not vB.
2,2 -Dimethylbutane has a reported log Kow of 3.82. Therefore, 2,2-dimethylbutane can be considered not B and not vB.
Toxicity (T) Assessment: As 2,2-dimethylbutane is not classified as persistent or bioaccumulative, a toxicity assessment is not required.
Human Health Hazards Assessment (T)
Carcinogenicity: There are no carcinogenicity data available for 2,2-dimethylbutane. Data for the read-across substance n-hexane do not warrant classification for carcinogenicity under Dir 67/548/EEC or GHS/CLP.
Mutagenicity: There are no mutagenicity data available for 2,2-dimethylbutane. Data for the read-across substances n-hexane do not warrant classification for mutagenicity under Dir 67/548/EEC or GHS/CLP.
Reproductive Toxicity: There are no reproductive toxicity data available for 2,2-dimethylbutane. Data for the read-across substances n-hexane warrant a classification of Repr 2. (H361f: suspected of damaging fertility or the unborn child) for reproductive toxicity under the Dir 67/548/EEC or GHS/CLP.
Chronic toxicity: Based on available read across data, 2,2-dimethylbutane is classified STOT RE 2 (H373: may cause damage to organs through prolonged or repeated exposure) for repeated dose toxicity under the Regulation (EC) 1272/2008 on classification, labelling and packaging of substances and mixtures (CLP).
Environmental Toxicity (T): There are no ecotoxicity data available for 2,2 -Dimethylbutane. The aquatic toxicity was therefore estimated using the Petrotox computer model (v. 3.06). The lowest predicted acute LL50 value for this range of data is 1.56 mg/L, reported for toxicity to algae. This is greater than the 0.01 mg/l limit for classification as T for the environment.
Therefore, 2,2-dimethylbutane is considered T based on the the classification of Repr 2. (H361f: suspected of damaging fertility or the unborn child) and STOT RE 2 (H373: may cause damage to organs through prolonged or repeated exposure).
Conclusion of PBT/vPvB assessment
Based on read-across to Hydrocarbons, C6, isoalkanes, <5% n-hexane 2,2-dimethylbutane can be considered readily biodegradable and therefore is not considered P or vP. Also, based on a reported log Kow of 3.82, 2,2-dimethylbutane is not considered B or vB. As such an assessment for T (toxicity) is not required.2,2-dimethylbutane is not classified as PBT or vP/vB.
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.