2-Propenenitrile, polymer with 1,2-ethanediamine

Adsorption / desorption

Administrative data

Endpoint:

adsorption / desorption: screening

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance has a low octanol water partition coefficient and the adsorption potential of this substance is related to this parameter

the study does not need to be conducted because the physicochemical properties of the substance indicate that it can be expected to have a low potential for adsorption

Justification for type of information:

The substance is functionally water soluble.
The Log Kow < 0 and adsorption to soils and sediments is not conisdered to be significant.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Justification for type of information:

The precise temperature was not recorded (methods followed are at 'ambient' temperature)
The pH was not reported (performed at 'natural' pH, ca pH 10)

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Specific details on test material used for the study:

Not specifed if material was 'water-free' (dried) material, but the presence of water would not make a difference with this method.

Analytical method:

high-performance liquid chromatography

Type:

log Pow

Partition coefficient:

< 0

Temp.:

20 °C

pH:

ca. 10

Remarks on result:

other: Precise figure not possible to determine

Details on results:

The test material eluted close to the solvent front and appeared not to be retained in the column, suggesting a Log Kow < 0
Only a single peak was observed using Refractive Index detector and Diode Array Detector.
The precise temperature was not recorded (methods followed are at 'ambient' temperature)
The pH was not adjusted.

Conclusions:

The very high water solubility would suggest that the partition coefficient is unlikely to be > 1 and despite some methodological deficiencies, the result is conclusive.
Only a single HPLC peak was reported, but in view of the type of column and mobile phase, the different speicies of the UVCB would not appear separate under the conditions of the test; this does however demonstrate that there are no minor components with a significant partition coefficient.

Cross-reference 2

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Justification for type of information:

Solublity limits based on manufacturing - the substance is manufactured and supplied in water

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

no

Type of method:

other: Direct observations

Specific details on test material used for the study:

Manufactured in water to give a solution > 40% actives
Water-free samples have been prepared

Water solubility:

> 570 g/L

Conc. based on:

test mat.

Loading of aqueous phase:

570 g/L

Temp.:

20 °C

pH:

ca. 10.8

Substance is manufactured and supplied in water.

Conclusions:

Loss on removal of water was 43%, suggesting ca 43% w/w water (ie ca 57% solution in water as manufactured)
The measured pH is 10.8