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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: the techniques specified in the Federal Insecticide, Fungicide, and Rodenticide Act (40 CFR 163).
- Principles of method if other than guideline:
- Five-tenths gram of the undiluted test material moistened with five-tenths milliliter physiological saline was applied on April 7, 1981, under a one-inch square surgical gauze patch, two layers thick, to two intact skin areas and two abraded skin areas on each of the six New Zealand White rabbits from J & J Research Farms, Inc.
- GLP compliance:
- no
- Remarks:
- GLP not mandatory at this date
Test material
- Reference substance name:
- Reaction mass of Trihydrogen [29H,31H-phthalocyaninetrisulphonato(5-)-N29,N30,N31,N32]cobaltate(3-) and [29H,31H-phthalocyaninato-N29,N30,N31,N32]cobalt and dihydrogen [29H,31H-phthalocyaninedisulphonato(4-)-N29,N30,N31,N32]cobaltate(2-) and hydrogen [29H,31H-phthalocyaninesulphonato(3-)-N29,N30,N31,N32]cobaltate(1-)
- Molecular formula:
- C32H16N8Co(SO3)n with n=0 to 3
- IUPAC Name:
- Reaction mass of Trihydrogen [29H,31H-phthalocyaninetrisulphonato(5-)-N29,N30,N31,N32]cobaltate(3-) and [29H,31H-phthalocyaninato-N29,N30,N31,N32]cobalt and dihydrogen [29H,31H-phthalocyaninedisulphonato(4-)-N29,N30,N31,N32]cobaltate(2-) and hydrogen [29H,31H-phthalocyaninesulphonato(3-)-N29,N30,N31,N32]cobaltate(1-)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: two intact skin areas and two abraded skin areas
- Vehicle:
- other: Moistened with 0.5ml physiological saline
- Controls:
- no
- Amount / concentration applied:
- 0.5g powder
- Duration of treatment / exposure:
- 24-hour exposure
- Observation period:
- 24 hours, and 72 hours
- Number of animals:
- 6
- Details on study design:
- Five-tenths gram of the undiluted test material moistened with five-tenths milliliter physiological saline was applied on April 7, 1981, under a one-inch square surgical gauze patch, two layers thick, to two intact skin areas and two abraded skin areas on each of the six New Zealand White rabbits from J & J Research Farms, Inc. The rabbits were individually identified by means of numbered ear tags. The application sites were prepared by clipping the hair from the saddle area of the rabbits. The abraded areas were prepared by making minor epidermal incisions with a hypodermic needle. The abrasions were sufficiently deep to penetrate the epidermis, but not to induce bleeding. Each patch was held in place with two strips of one-inch adhesive tape. After application of the patches,
the trunk of each rabbit was wrapped with rubber dental damming, which was secured with staples. An outer layer of gauze and tape was placed around the trunk of each animal.
At the end of the exposure period, the patches were removed and any residual sample was gently sponged from the skin with a moistened towel.
The reactions were scored immediately after removal of the patches (24-hour reading), and again two days later at 73 to 73 1/4 hours post-dosing (72-hour reading),
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- Scoring at 48 hours not performed
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.17
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Remarks:
- Scoring at 48 hours not performed
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- not specified
- Irritant / corrosive response data:
- Irritative effects noted during the cours-e of the study included mild erythema which was observed at abraded or intact sites of five animals. Very slight edema scores were noted in one animal on abraded sites. Most skin irritation was absent by the 72-hour reading. No evidence of corrosivity was found.
The Primary Irritation Index was found to be 0.4.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under tests conditions and based on GHS criteria, the test item is not classified due to the low Primary Irritation Index score (0,4).
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