Soybean meal, protein extn. residue

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

16 April 2018 to 19 April 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: vapour pressure balance

Key result

Test no.:

#1

Temp.:

25 °C

Vapour pressure:

< 0.003 Pa

Table 1 – Run 8 Vapour Pressure Data

Temperature (°C)	Temperature (K)	Reciprocal Temperature K^-1)	Mass Difference (µg)	Mass Difference (kg)	Vapour Pressure (Pa)	Log10 Vp
80	353.15	0.002832	7.39	7.39e-09	0.01026	-1.98885
81	354.15	0.002824	5.09	5.09e-09	0.00707	-2.15058
82	355.16	0.002816	5.09	5.09e-09	0.00707	-2.15058
83	356.15	0.002808	4.59	4.59e-09	0.00637	-2.19586
84	357.15	0.002800	4.49	4.49e-09	0.00623	-2.20551
85	358.15	0.002792	4.29	4.29e-09	0.00596	-2.22475
86	359.15	0.002784	4.19	4.19e-09	0.00582	-2.23508
87	360.15	0.002777	4.69	4.69e-09	0.00651	-2.18642
88	361.15	0.002769	5.69	5.69e-09	0.00790	-2.10237
89	362.15	0.002761	5.89	5.89e-09	0.00818	-2.08725
90	363.15	0.002754	8.09	8.09e-09	0.01123	-1.94962

No statistical analysis is given due to the nature of the plot.

 

Table 2 – Run 9 Vapour Pressure Data

Temperature (°C)	Temperature (K)	Reciprocal Temperature K^-1)	Mass Difference (µg)	Mass Difference (kg)	Vapour Pressure (Pa)	Log10 Vp
80	353.15	0.002832	6.99	6.99e-09	0.00970	-2.01323
81	354.15	0.002824	6.09	6.09e-09	0.00845	-2.07314
82	355.16	0.002816	6.39	6.39e-09	0.00887	-2.05208
83	356.15	0.002808	4.69	4.69e-09	0.00651	-2.18642
84	357.15	0.002800	5.89	5.89e-09	0.00818	-2.08725
85	358.15	0.002792	5.59	5.59e-09	0.00776	-2.11014
86	359.15	0.002784	5.89	5.89e-09	0.00818	-2.08725
87	360.15	0.002777	5.09	5.09e-09	0.00707	-2.15058
88	361.15	0.002769	5.39	5.39e-09	0.00748	-2.12610
89	362.15	0.002761	5.79	5.79e-09	0.00804	-2.09474
90	363.15	0.002754	4.99	4.99e-09	0.00693	-2.15927

No statistical analysis is given due to the nature of the plot.

 

Table 3 – Run 10 Vapour Pressure Data

Temperature (°C)	Temperature (K)	Reciprocal Temperature K^-1)	Mass Difference (µg)	Mass Difference (kg)	Vapour Pressure (Pa)	Log10 Vp
80	353.15	0.002832	3.79	3.79e-09	0.00526	-2.27901
81	354.15	0.002824	4.29	4.29e-09	0.00596	-2.22475
82	355.15	0.002816	4.09	4.09e-09	0.00568	-2.24565
83	356.15	0.002808	4.69	4.69e-09	0.00651	-2.18642
84	357.15	0.002800	4.49	4.49e-09	0.00623	-2.20551
85	358.15	0.002792	4.59	4.59e-09	0.00637	-2.19586
86	359.15	0.002784	4.09	4.09e-09	0.00568	-2.24565
87	360.15	0.002777	4.39	4.39e-09	0.00609	-2.21538
88	361.15	0.002769	5.79	5.79e-09	0.00804	-2.09474
89	362.15	0.002761	4.79	4.79e-09	0.00665	-2.17718
90	363.15	0.002754	7.09	7.09e-09	0.00984	-2.00700

No statistical analysis is given due to the nature of the plot.

 

Discussion

- The test material did not change in appearance under the conditions used in the determination.

- No statistical analyses were performed because the balance readings were too low and variable for a line of best fit to have any meaning. Instead it was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate of the maximum value for the vapour pressure at 25 °C.

- Run 10 was chosen because the sample had been under vacuum for the longest period prior to this run and so degassing would have been the most complete. The reading at 90 °C (363.15 K) was chosen because this is the data point which gives the highest estimated vapour pressure at any given temperature when a slope of –1000 K is imposed upon it.

- The value of –1000 K is an in-house value and is the shallowest slope observed whilst determining the vapour pressure on a wide range of samples using the vapour pressure balance method. Extrapolation to 25 °C gave a vapour pressure of 2.47 x 10^-3 Pa which has been taken as a maximum for this material.

Conclusions:

Under the conditions of this study, the vapour pressure of the test material has been determined to be less than 2.5 x 10^-3 Pa at 25 °C.

Executive summary:

The vapour pressure of the test material was investigated in accordance with the standardised guidelines OECD 104 and EU Method A.4., under GLP conditions.

The vapour pressure was determined using a vapour pressure balance. A sequence of runs was started after a sample of test material had been under vacuum for approximately 24.0 hours. Temperature and pressure readings were taken between 80 and 90 °C with a one hour dwell at 80 °C between runs.

The test material did not change in appearance under the conditions used in the determination. No statistical analyses were performed because the balance readings were too low and variable for a line of best fit to have any meaning. Instead it was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate of the maximum value for the vapour pressure at 25 °C. Run 10 was chosen because the sample had been under vacuum for the longest period prior to this run and so degassing would have been the most complete. The reading at 90 °C (363.15 K) was chosen because this is the data point which gives the highest estimated vapour pressure at any given temperature when a slope of –1000 K is imposed upon it.

Under the conditions of this study, the vapour pressure of the test material has been determined to be less than 2.5 x 10^-3 Pa at 25 °C.

Description of key information

Under the conditions of this study, the vapour pressure of the test material has been determined to be less than 2.5 x 10^-3 Pa at 25 °C.

Additional information

The vapour pressure of the test material was investigated in accordance with the standardised guidelines OECD 104 and EU Method A.4., under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

The vapour pressure was determined using a vapour pressure balance. A sequence of runs was started after a sample of test material had been under vacuum for approximately 24.0 hours. Temperature and pressure readings were taken between 80 and 90 °C with a one hour dwell at 80 °C between runs.

The test material did not change in appearance under the conditions used in the determination. No statistical analyses were performed because the balance readings were too low and variable for a line of best fit to have any meaning. Instead it was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate of the maximum value for the vapour pressure at 25 °C. Run 10 was chosen because the sample had been under vacuum for the longest period prior to this run and so degassing would have been the most complete. The reading at 90 °C (363.15 K) was chosen because this is the data point which gives the highest estimated vapour pressure at any given temperature when a slope of –1000 K is imposed upon it.

Under the conditions of this study, the vapour pressure of the test material has been determined to be less than 2.5 x 10^-3 Pa at 25 °C.