Registration Dossier
Registration Dossier
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EC number: 241-240-8 | CAS number: 17199-29-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
- Principles of method if other than guideline:
- Estimate of the potential acute hazard after single administration (determination of LD50 after 14 days).
- GLP compliance:
- no
- Test type:
- other: Estimate of the potential acute hazard after single administration
Test material
- Reference substance name:
- D-2-hydroxy-2-phenylacetic acid
- EC Number:
- 241-240-8
- EC Name:
- D-2-hydroxy-2-phenylacetic acid
- Cas Number:
- 17199-29-0
- Molecular formula:
- C8H8O3
- IUPAC Name:
- hydroxy(phenyl)acetic acid
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: stainless steel wire mesh cages
- Diet : ad libitum (no feed about 16 hrs before administration)
- Water (e.g. ad libitum): tap water ad libitum per day
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24 °C
- Humidity (%): 30-70%
- Air changes (per hr): fully air-conditioned rooms, central air-conditioning
- Photoperiod (hrs dark / hrs light): 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
The substance was formulated with olive oil. Test substance is insoluble in water suspension.
Amounts administered:
Dose mg/kg: 5000 3160 1470
Conc w/v: 50.0 63.2 29.4
Adm.vol ml/kg: 10 5 5
- Doses:
- Single oral administration
- No. of animals per sex per dose:
- 5 males, 5 females
5 animals per cage - Details on study design:
- Observation period: 14 days
Recording of signs and symptoms several timeson the day of administration, at least once each workday, check for moribund and dead animals twice each workday and once on holidays.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4 490 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 160 mg/kg bw
- Based on:
- test mat.
- Mortality:
- see attachment
- Gross pathology:
- No abnormalities detected.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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