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EC number: 205-532-9 | CAS number: 142-29-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Principles of method if other than guideline:
- BASF test:
0.05 ml of the undiluted test substance was applied to each one eye of two white Vienna rabbits. The test material was not washed out. The two animals were observed for 8 days and eye irritation was observed on working days. Findings were recorded after 24, 48 and 72 hours as well as on day 6 and at the end of the observation period on day 8. Findings were graded as described in OECD test guideline 405. - GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Gaukler
- Weight at study initiation: 3.02 and 2.9 kg
- Diet: ad libitum
- Water: ad libitum - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.05 ml - Duration of treatment / exposure:
- at least 24 hours, test substance was not washed out
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no washing done
SCORING SYSTEM:
BASF scheme
cornea score (Tr):
+ corresponds to Draize score 1
+-++ corresponds to Draize score 2
++ corresponds to Draize score 3
+++ corresponds to Draize score 4
iris score:
ciliare injection corresponds to Draize score 1
iritis corresponds to Draize score 2
conjuntivae score
R+ corresponds to Draize score 1
R++ corresponds to Draize score 2
R+++ corresponds to Draize score 3
chemosis score
Ö (+) corresponds to Draize score 1
Ö+ corresponds to Draize score 2
Ö++ corresponds to Draize score 3
Ö+++ corresponds to Draize score 3-4
Readings were performed 24, 48 and 72 hours and 6 and 8 days after the application. - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 6 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicalbe
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material only led to slight signs of irritation (Grade 1 redness of the conjunctivae in both animals) after 24/48/72 hours. The effects were fully reversible within 6 days. Thus, no classification for eye irritation is necessary.
- Executive summary:
In this study, the eye irrtiaiton potential of cyclohexene was investigated. Briefly, 0.05 ml of the undiluted test substance was applied to each one eye of two white Vienna rabbits. The test material was not washed out. The two animals were observed for 8 days and eye irritation was observed on working days. Findings were recorded after 24, 48 and 72 hours as well as on day 6 and at the end of the observation period on day 8. Findings were graded as described in OECD test guideline 405.
The test material only led to slight signs of irritation (Grade 1 redness of the conjunctivae in both animals) after 24/48/72 hours. The effects were fully reversible within 6 days. Thus, no classification for eye irritation is necessary.
|
Animal 1 |
Animal 2 |
||||||
|
Corn. |
Iris |
Conj. |
Chem. |
Corn. |
Iris |
Conj. |
Chem. |
24 h |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
48 h |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
72 h |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
6/8 d |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Mean 24, 48 and 72 h |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- BASF test:
0.05 ml of the undiluted test substance was applied to each one eye of two white Vienna rabbits. The test material was not washed out. The two animals were observed for 8 days and eye irritation was observed on working days. Findings were recorded after 24, 48 and 72 hours as well as on day 6 and at the end of the observation period on day 8. Findings were graded as described in OECD test guideline 405. - GLP compliance:
- no
Test material
- Reference substance name:
- Cyclohexene
- EC Number:
- 203-807-8
- EC Name:
- Cyclohexene
- Cas Number:
- 110-83-8
- Molecular formula:
- C6H10
- IUPAC Name:
- cyclohexene
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Gaukler
- Weight at study initiation: 3.02 and 2.9 kg
- Diet: ad libitum
- Water: ad libitum
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.05 ml - Duration of treatment / exposure:
- at least 24 hours, test substance was not washed out
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no washing done
SCORING SYSTEM:
BASF scheme
cornea score (Tr):
+ corresponds to Draize score 1
+-++ corresponds to Draize score 2
++ corresponds to Draize score 3
+++ corresponds to Draize score 4
iris score:
ciliare injection corresponds to Draize score 1
iritis corresponds to Draize score 2
conjuntivae score
R+ corresponds to Draize score 1
R++ corresponds to Draize score 2
R+++ corresponds to Draize score 3
chemosis score
Ö (+) corresponds to Draize score 1
Ö+ corresponds to Draize score 2
Ö++ corresponds to Draize score 3
Ö+++ corresponds to Draize score 3-4
Readings were performed 24, 48 and 72 hours and 6 and 8 days after the application.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 6 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicalbe
Any other information on results incl. tables
|
Animal 1 |
Animal 2 |
||||||
|
Corn. |
Iris |
Conj. |
Chem. |
Corn. |
Iris |
Conj. |
Chem. |
24 h |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
48 h |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
72 h |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
6/8 d |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Mean 24, 48 and 72 h |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material only led to slight signs of irritation (Grade 1 redness of the conjunctivae in both animals) after 24/48/72 hours. The effects were fully reversible within 6 days. Thus, no classification for eye irritation is necessary.
- Executive summary:
In this study, the eye irrtiaiton potential of cyclohexene was investigated. Briefly, 0.05 ml of the undiluted test substance was applied to each one eye of two white Vienna rabbits. The test material was not washed out. The two animals were observed for 8 days and eye irritation was observed on working days. Findings were recorded after 24, 48 and 72 hours as well as on day 6 and at the end of the observation period on day 8. Findings were graded as described in OECD test guideline 405.
The test material only led to slight signs of irritation (Grade 1 redness of the conjunctivae in both animals) after 24/48/72 hours. The effects were fully reversible within 6 days. Thus, no classification for eye irritation is necessary.
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