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EC number: 263-000-1 | CAS number: 61788-71-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-04-03 to 2018-05-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- yes
- Remarks:
- Two vessels were set up in a parallel design, each vessel was sampled several times instead of sampling one vessel at every point in time/ exclusion of O2 and CO2, under inert gas (argon)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- yes
- Remarks:
- Two vessels were set up in a parallel design, each vessel was sampled several times instead of sampling one vessel at every point in time/ exclusion of O2 and CO2, under inert gas (argon)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 2016-05-31
- Type of method:
- flask method
- Specific details on test material used for the study:
- Storage conditions: Room temperature tightly closed
- Key result
- Water solubility:
- 486 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 1 g/L
- Incubation duration:
- >= 34 - <= 35 d
- Temp.:
- 20 °C
- pH:
- >= 6.7 - <= 7.5
- Remarks on result:
- other: S.D.: ± 74.6 mg/L
- Remarks:
- calculated based on a ni content of 10.55 % and a purity of 90 % (w/w)
- Water solubility:
- 56.9 mg/L
- Conc. based on:
- element (dissolved fraction)
- Remarks:
- Ni
- Loading of aqueous phase:
- 1 g/L
- Incubation duration:
- >= 34 - <= 35 d
- Temp.:
- 20 °C
- pH:
- >= 6.7 - <= 7.5
- Remarks on result:
- other: S.D.± 8.75 mg/L
- Details on results:
- - Temperatire: 20.0 ± 0.2 °C
- pH values:
solutions containing test item: from 6.7 – 6.9 (day 1) to 7.3 – 7.5 (day 34); 7.1 – 7.2 (day 35)
method blanks: from 5.9 – 6.4 (day 1) to 5.6 – 6.2 (day 35)
- The turbidity in samples from test was always <1 NTU indicating that filtered solutions did not contain any undissolved material. - Conclusions:
- Under the conditions of this test (under exclusion of CO2 and O2, under inert gas; flask method; loadings of 1.003 g and 1.002 g/L test substance in vessel 1 and 2, respectively), a solubility equilibrium was reached at day 34, 35 of testing. The mean measured amount of dissolved nickel on day 34 and 35 at 20 ± 1°C is 56.9 ± 8.75 mg/L (determined as dissolved nickel, separated by filtration from undissolved test item). This corresponds to a water solubility of dissolved naphthenic acids, nickel salts of 486 ± 74.6 mg/L, calculated based on a nickel content of 10.55 % and a test substance purity of 90% (w/w). Solution pH in samples containing the test item remained at 6.7 – 7.5 while the pH in method blanks ranged from 5.6 – 6.4.
Reference
ICP-OES
ICP-OES measurement with corresponding LOD/LOQ, correlation coefficient and sum of quality assurance samples and recovery
date |
Chosen wavelength [nm] |
LOD |
LOQ |
correlation coefficient |
Sum of quality assurance samples |
Recovery / validity of quality assurance samples [%] |
April 26, 2018; measurement of test samples (21d and 22d) and method blanks |
Ni: 231.604 |
Ni: 1.11 |
Ni: 3.33 |
Ni: 0.99996 |
Ni: 10 |
Ni: 100 |
Recovery/validation data nickel of measurement April 26, 2018
|
Recovery [%] |
SD [%] |
n (total) |
n (valid) |
TMDA-70.2 (dilution factor 2), nominal value Ni: 333 µg/L – diluted 167 µg/L |
105 |
0.6 |
3 |
3 |
Quality control standard (Roth) 300 µg/L |
105 |
0.3 |
3 |
3 |
Recalibration standard 100 µg/L |
101 |
0.7 |
3 |
3 |
Fortification of measurement series April 26, 2018
Sample |
element |
measured concentration [µg/L] |
calculated level after addition [µg/L] |
recovery |
Vessel 1 sample a 21d – 1 mL sample 4 mL 400 µg/L standard |
Ni |
410 |
402 |
405 / 101 |
ICP-MS
ICP-MS measurement with corresponding LOD/LOQ, correlation coefficient and sum of quality assurance samples and recovery
Chosen isotope and gas mode |
LOD |
LOQ |
correlation coefficient |
Sum of quality assurance samples |
Recovery / validity of quality assurance samples [%] |
April 10, 2018; measurement of samples of the main test 1, 2 and 3 d |
|||||
Ni:60Ni [Helium mode] |
Ni: 0.006 |
Ni: 0.019 |
Ni: 0.9999 |
Ni: 13 |
Ni: 100 |
April 19, 2018; measurement of samples of the main test 13 d and 14 d |
|||||
Ni:60Ni [noGas mode] |
Ni: 0.015 |
Ni: 0.046 |
Ni: 1.0000 |
Ni: 10 |
Ni: 100 |
May 07, 2018; measurement of samples of the main test 34 d |
|||||
Ni:60Ni [HiHelium mode] |
Ni: 0.006 |
Ni: 0.017 |
Ni: 0.9995 |
Ni: 7 |
Ni: 100 |
May 08, 2018; measurement of samples of the main test 35 d and remeasurement of 34 d –only test item samples |
|||||
Ni:60Ni [Helium mode] |
Ni: 0.005 |
Ni: 0.016 |
Ni: 1.0000 |
Ni: 14 |
Ni: 100 |
Recovery/validation data nickel of measurement
|
Recovery [%] |
SD [%] |
n (total) |
n (valid) |
|
April 10, 2018 |
|||||
TMDA-70.2 (dilution factor 2), nominal value Ni: 333 µg/L – diluted 167 µg/L |
101 |
2.4 |
4 |
4 |
|
Quality control standard (Roth) 250 µg/L |
107 |
1.9 |
4 |
4 |
|
Recalibration standard 100 µg/L |
97.8 |
1.8 |
4 |
4 |
|
April 19, 2018 |
|||||
TMDA-70.2 (dilution factor 4), nominal value Ni: 333 µg/L – diluted 83.3 µg/L |
99.6 |
1.43 |
3 |
3 |
|
Quality control standard (Roth) 250 µg/L |
104 |
4.7 |
3 |
3 |
|
Recalibration standard 100 µg/L |
96.6 |
0.9 |
3 |
3 |
|
May 07, 2018 |
|||||
TMDA-70.2 (dilution factor 2), nominal value |
100 |
0.5 |
2 |
2 |
|
Quality control standard (Roth) 400 µg/L |
101 |
0.4 |
2 |
2 |
|
Recalibration standard 100 µg/L |
102 |
2.2 |
3 |
3 |
|
May 08, 2018 |
|||||
TMDA-70.2 (dilution factor 2), nominal value Ni: 333 µg/L – diluted 167 µg/L |
101 |
2.6 |
4 |
4 |
|
Quality control standard (Roth) 400 µg/L |
98.0 |
2.5 |
4 |
4 |
|
Recalibration standard 100 µg/L |
96.7 |
1.6 |
4 |
4 |
Ni fortification
sample |
Element |
measured concentration [µg/L] |
calculated level after addition [µg/L] |
recovery |
April 10, 2018 |
||||
Vessel 1 sample a 2 d sampling time (dilution factor 100) - 1 mL sample + 4 mL of standard 100 µg/L |
Ni |
149 |
110 |
108 / 98.4 |
April 19, 2018. |
||||
Vessel 1 sample a 14 d sampling time (dilution factor 100) - 1 mL sample + 4 mL of standard 300 µg/L |
Ni |
290 |
298 |
293 / 98.2 |
May 08, 2018. |
||||
Vessel 1 sample a 34 d sampling time (dilution factor 200) - 1 mL sample + 4 mL of standard 300 µg/L |
Ni |
326 |
305 |
307 / 101 |
Vessel 1 sample a 35 d sampling time (dilution factor 200) - 1 mL sample + 4 mL of standard 300 µg/L |
Ni |
308 |
302 |
299 / 99.1 |
Description of key information
According to OECD Guideline 105 (1995) and EU Method 440/2008 A.6, the test item naphthenic acids, nickel salts has a water solubility of 486 mg/L at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 486 mg/L
- at the temperature of:
- 20 °C
Additional information
Under the conditions of this test (under exclusion of CO2and O2, under inert gas; flask method; loadings of 1.003 g and 1.002 g/L test substance in vessel 1 and 2, respectively), a solubility equilibrium was reached at day 34, 35 of testing. The mean measured amount of dissolved nickel on day 34 and 35 at 20 ± 1 °C is 56.9 ± 8.75 mg/L (determined as dissolved nickel, separated by filtration from undissolved test item). This corresponds to a water solubility of dissolved naphthenic acids, nickel salts of 486 ± 74.6 mg/L, calculated based on a nickel content of 10.55 % and a test substance purity of 90 % (w/w). Solution pH in samples containing the test item remained at 6.7 – 7.5 while the pH in method blanks ranged from 5.6 – 6.4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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