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EC number: 309-363-2 | CAS number: 100231-63-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Remarks:
- Summary of available data used for the assessment of this endpoint for the target substance.
- Adequacy of study:
- key study
- Justification for type of information:
- Refer to the analogue approach justification provided in IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- Source: RA-A, CAS 31387-97-0, Inst. Techn. FCBA, 2010, D. magna
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 51 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- Source: RA-A, CAS 31387-97-0, Inst. Techn. FCBA, 2010, D. magna
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 490 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL: 420 - 580 mg a.i./L
- Remarks:
- Source: RA-A, CAS 54549-24-5, Wetton, 1998, D. magna
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 180 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Remarks on result:
- other:
- Remarks:
- Source: RA-A, CAS 54549-24-5, Wetton, 1998, D. magna
- Conclusions:
- The key effect concentration retained for the assessment of the short-term toxicity of the target substance to aquatic invertebrates is an EC50 (48 h) of > 51 mg/L (act. ingr., OECD 202, D. magna, CAS 31387-97-0) based on the available read-across data.
Reference
Description of key information
EC50 (48 h) > 51 mg a.i./L (nominal, OECD 202, D. magna); read-across
EC50 (48 h) = 490 mg a.i./L (nominal, OECD 202, D. magna); read-across
Key value for chemical safety assessment
Additional information
There is no study available, in which the short-term toxicity of the target substance D-Glucopyranose, oligomeric, pentyl glycosides (CAS 100231-63-8) to aquatic invertebrates was assessed. Therefore, read-across to the two structurally and chemically closely related source substances D-Glucopyranose, oligomeric, butyl glycoside (CAS 31387-97-0) and D-Glucopyranose, oligomers, hexyl glycosides (CAS 54549-24-5) was performed in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 in order to meet the standard information requirements laid down in Annex VII of REACh Regulation (EC) No 1907/2006. Based on the high degree of physico-chemical similarity between the target and source substances, the selected source substances are considered suitable representatives for the assessment of the short-term toxicity of the target substance to aquatic invertebrates. A detailed read-across approach justification is provided in IUCLID section 13.
By means of the read-across approach, two key and two supporting studies are available for the assessment of the short-term toxicity of the target substance to aquatic invertebrates. All the available studies complied with GLP.
For the source substance D-Glucopyranose, oligomeric, butyl glycoside (CAS 31387-97-0), one key study is available, in which D. magna was exposed to nominal test item concentrations of 1, 10, and 100 mg/L of a 51% test item solution in a semi-static test design for 48 h (Inst. Techn. FCBA, 2010). The study was performed according to OECD 202. The actual test item concentration of the highest testing level was verified by TOC and resulted in 88.7 - 104.4% TOC recovery. After 48 h, no immobilization was observed, resulting in an EC50 (48 h) of > 100 mg/L (nominal), equivalent to > 51 mg a.i./L, the highest concentration tested.
For the source substance D-Glucopyranose, oligomers, hexyl glycosides (CAS 54549-24-5) two freshwater studies and one saltwater study are available. Neither study analytically verified the actual test item concentrations in the test vessels. The freshwater studies (key and supporting) were performed according to OECD guideline 202 using Daphnia magna. The key study (Wetton, 1998) resulted in an EC50 (48 h) of 490 mg a.i./L (nominal) and the supporting study (Wetton, 1997) resulted in an EC50 (48 h) of > 100 mg/L (test material, nominal).
The available supporting saltwater test (Larsen, 2003) was performed equivalently to ISO 14669 using Acartia tonsa as model organism and resulted in an LL50 (48 h) of 730 mg/L (nominal loading rate of water accommodated fraction).
Thus, the available results taken together indicate no hazard to aquatic invertebrates.
Based on the high degree of structural and physico-chemical similarity between the target and the selected source substances, the target substance is expected to exhibit a similar ecotoxicological profile as the source substances. Therefore, the target substance D-Glucopyranose, oligomeric, pentyl glycosides (CAS 100231-63-8) is not expected to cause toxic effects to aquatic invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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