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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 827-581-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 11.8 mg/m³
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 75
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 882 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Dose descriptor There are no data available in humans or laboratory animals relating to fertility effects following repeated inhalation exposure to SCMI or read across material. There is however an oral screening study performed to OECD 421 on SCI that achieved a NOAEL. Therefore, the NOAEL of 1000 mg/kg bw/day on from this screening study on SCI will be used for the calculation of the inhalation DNEL (fertility ). SCMI is considered to have only threshold effects, as the weight-of-evidence indicates that it does not possess genotoxic potential.
- AF for dose response relationship:
- 1
- Justification:
- Default ECHA AF; human health relevant NOAEL from well-conducted 28day screening study
- AF for differences in duration of exposure:
- 6
- Justification:
- Default ECHA AF for Screening study (sub acute) exposure
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- A health precautionary approach is to assume 100% absorption following inhalation exposure. Therefore, the starting point has been corrected to reflect 50% oral absorption and 100% inhalation absorption. Thus, 1000mg/kg bw/day / (100/50) = 500 mg/kg bw/day. Workers are assumed to be exposed for 8 h/day. The oral dose for the rat is converted to the corresponding air concentration, using a standard breathing volume for the rat, of 0.38 m3/kg bw for 8 h/day (exposure of workers). To account for the presumed light activity of workers, this value has been corrected for an increase in breathing volume. Thus (500 mg/kg bw/day / 0.38 m3/kg bw/day) x 0.67 m3 = 882 mg/m3(8-h exposure of workers, light activity).
- AF for other interspecies differences:
- 2.5
- Justification:
- Default ECHA AF for remaining toxicokinetic differences (not related to metabolic rate) and toxicodynamic differences
- AF for intraspecies differences:
- 5
- Justification:
- Default ECHA AF for (healthy) worker
- AF for the quality of the whole database:
- 1
- Justification:
- Default ECHA AF; the health effects data are reliable and consistent, the available information meets the tonnage driven data requirements, and confidence in the database is high
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.3 mg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- There are no data available in humans relating to repeated dermal exposure which are suitable as the basis from which to calculate a dermal DNEL for fertility. There is however an oral screening study performed to OECD 421 on SCI that achieved a NOAEL. Therefore, the NOAEL of 1000 mg/kg bw/day on from this screening study on SCI will be used for the calculation of the dermal DNEL (fertility). Mode-of-action SCI is considered to have only threshold effects, as the weight-of-evidence indicates that they do not possess genotoxic potential. Modification of starting point In the absence of any data to the contrary, the same bioavailability is assumed for humans and laboratory animals. As no relevant study data on effects of repeated dermal exposure to SCI in humans or laboratory animals are available, route-to-route extrapolation to calculate a dermal DN(M)EL from repeated dose oral toxicity studies was considered a suitable alternative. In the absence of route-specific information on absorption the end route (dermal), a conservative assumption equal to the oral absorption will be made. Therefore, the starting point is 1000 mg/kg/bw/day. Workers are assumed to be exposed for 8 h/day.
- AF for dose response relationship:
- 1
- Justification:
- Default ECHA AF; human health relevant NOAEL from well-conducted 28day screening study
- AF for differences in duration of exposure:
- 6
- Justification:
- Default ECHA AF for screening study (sub acute) exposure
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default ECHA AF for rat for toxicokinetic differences in metabolic rate (allometric scaling)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default ECHA AF for remaining toxicokinetic differences (not related to metabolic rate) and toxicodynamic differences
- AF for intraspecies differences:
- 5
- Justification:
- Default ECHA AF for (healthy) worker
- AF for the quality of the whole database:
- 1
- Justification:
- Default ECHA AF; the health effects data are reliable and consistent, the available information meets the tonnage driven data requirements, and confidence in the database is high
Acute/short term exposure
- Hazard assessment conclusion:
- no DNEL required: short term exposure controlled by conditions for long-term
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
Toxicity studies on SCI and reproductive / developmental toxicity screening studies on SLI predict that SCMI is of low toxicity following acute or repeated dose exposure. There was no evidence of genotoxicity or effects on reproductive performance and development of offspring. SCMI is predicted to cause slight skin irritation and reversible eye irritation. Based on the available data and evidence, SCMI is not expected to cause skin sensitisation.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5.9 mg/m³
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 150
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 882 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- In the absence of any data to the contrary, the same bioavailability is assumed for humans and laboratory animals. Route-to-route extrapolation to calculate an inhalation DNEL (fertility) from oral studies was considered suitable. A health precautionary approach is to assume 100% absorption following inhalation exposure. Therefore, the starting point has been corrected to reflect 50% oral absorption and 100% inhalation absorption. Thus, 1000mg/kg bw/day / (100/50) = 500 mg/kg bw/day. General populations are assumed to be exposed for 8 h/day. The oral dose for the rat is converted to the corresponding air concentration, using a standard breathing volume for the rat, of 0.38 m3/kg bw for 8 h/day (exposure of general populations). To account for the presumed light activity of general populations, this value has been corrected for an increase in breathing volume. Thus (500 mg/kg bw/day / 0.38 m3/kg bw/day) x 0.67 m3 = 882 mg/m3(8-h exposure of general populations, light activity).
- AF for dose response relationship:
- 1
- Justification:
- Default ECHA AF; human health relevant NOAEL from well-conducted 28day screening study
- AF for differences in duration of exposure:
- 6
- Justification:
- Default ECHA AF for Screening study (sub acute) exposure
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allometric scaling already considered in correcting starting point above
- AF for other interspecies differences:
- 2.5
- Justification:
- Default ECHA AF for remaining toxicokinetic differences (not related to metabolic rate) and toxicodynamic differences
- AF for intraspecies differences:
- 10
- Justification:
- Default ECHA AF for (healthy) general population
- AF for the quality of the whole database:
- 1
- Justification:
- Default ECHA AF; the health effects data are reliable and consistent, the available information meets the tonnage driven data requirements, and confidence in the database is high
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.7 mg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- In the absence of any data to the contrary, the same bioavailability is assumed for humans and laboratory animals. As no relevant study data on effects of repeated dermal exposure to SCI in humans or laboratory animals are available, route-to-route extrapolation to calculate a dermal DN(M)EL from repeated dose oral toxicity studies was considered a suitable alternative. In the absence of route-specific information on absorption the end route (dermal), a conservative assumption equal to the oral absorption will be made. Therefore, the starting point is 1000 mg/kg/bw/day. General populations are assumed to be exposed for 8 h/day
- AF for dose response relationship:
- 1
- Justification:
- Default ECHA AF; human health relevant NOAEL from well-conducted 28day screening study
- AF for differences in duration of exposure:
- 6
- Justification:
- Default ECHA AF for screening study (sub acute) exposure
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default ECHA AF for rat for toxicokinetic differences in metabolic rate (allometric scaling)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default ECHA AF for remaining toxicokinetic differences (not related to metabolic rate) and toxicodynamic differences
- AF for intraspecies differences:
- 10
- Justification:
- Default ECHA AF for (healthy) general population
- AF for the quality of the whole database:
- 1
- Justification:
- Default ECHA AF; the health effects data are reliable and consistent, the available information meets the tonnage driven data requirements, and confidence in the database is high
Acute/short term exposure
- Hazard assessment conclusion:
- no DNEL required: short term exposure controlled by conditions for long-term
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.8 mg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 484 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- SCMI is considered to have only threshold effects, as the weight-of-evidence indicates that it does not possess genotoxic potential. In the absence of any data to the contrary, the same bioavailability is assumed for humans and laboratory animals. The starting point of SI must be corrected for the change in MW for SCMI (average is 358 g/mol). So, 200 mg/kg/bw/d*(358/148.11) = 484mg/kg/bw/day General populations are assumed to be exposed for 24 h/day
- AF for dose response relationship:
- 1
- Justification:
- Default ECHA AF; human health relevant NOAEL from well-conducted 28day screening study
- AF for differences in duration of exposure:
- 6
- Justification:
- Default ECHA AF for Screening study (sub acute) exposure
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default ECHA AF for rat for toxicokinetic differences in metabolic rate (allometric scaling)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default ECHA AF for remaining toxicokinetic differences (not related to metabolic rate) and toxicodynamic differences
- AF for intraspecies differences:
- 10
- Justification:
- Default ECHA AF for (healthy) general population
- AF for the quality of the whole database:
- 1
- Justification:
- Default ECHA AF; the health effects data are reliable and consistent, the available information meets the tonnage driven data requirements, and confidence in the database is high
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - General Population
Toxicity studies on SCI and reproductive / developmental toxicity screening studies on SLI predict that SCMI is of low toxicity following acute or repeated dose exposure. There was no evidence of genotoxicity or effects on reproductive performance and development of offspring. Based on the available read-across data SCMI is predicted to cause slight skin irritation and reversible eye irritation but is not expected to cause skin sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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