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EC number: 701-129-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Under the experimental conditions, the oral LD50 of the test item was found to be greater than 2000 mg/kg ww in rats
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
The acute oral toxicity in rats was determined according the method recommanded in the OECD Guideline No. 423, "Acute Oral Toxicity - ACUTE TOXIC CLASS METHOD", 22nd March 1996, and the EU-Guideline B.1 "Acute Toxicity(Oral) - ACUTE TOXIC CLASS METHOD", January 1997.
The study was carried out with one group consisting of three male and three female animals given a dose of 2000 mg/kg bw. The following clinical signs were observed:
Females: Animals No. 1, No. 2 and No. 3 showed piloerection 1,3 and 6 hours after the application of the test article. From Day 1 until the end of the observation period on Day 14 no abnormalities were revealed in the three rats.
Males: Animals No. 4, No. 5 and No. 6 showed a pinched abdomen and piloerection 1 hour after the application of the test article. After 3 and 6 hours piloerection was still observed. From Day 1 until the end of the observation period on Day 14 no abnormalities were revealed.
Necropsy: The gross necropsy of the female and male animals revealed no pathological abnormalities.
Conclusion: Under the the experimental conditions described in this study, the oral LD50 of the test item in rats was found to be above 2000 mg/kg bw.
In an acute dermal toxicity study (OECD 402 Limit Test), young adult Wistar rats (5 males and 5 females) were dermally exposed to a single dose of 5000 mg/kg bw of the undiluted test item D-Glucopyranose, 6-O-(carboxymethyl)-, Oligomer, C12-14-alkyl glycosidet, sodium salt to the clipped skin (dorsal and dorso-lateral parts of the trunk) and covered by semi-occlusive dressing for 24 hours. The application area comprised at least 10% of the total body surface area. The animals were observed for 14 days. · No mortality occurred · No clinical findings were observed · The following test item-related local effects were recorded during the course of the study: Erythema grade 1 to 4, Edema grade 1 to 4, Incrustations, Incrustations partly detached, Scaling · The mean body weight of the animals increased within the normal range throughout the study period. · No macroscopic pathologic abnormalities were noted in the animals examined at the end of the study. Accordingly, the acute dermal median lethal dose (LD50) was determined to be LD50, dermal, rat > 5000 mg/kg bw
Justification for selection of acute toxicity – dermal endpoint
Klimisch 1 study
Justification for classification or non-classification
No classification and labelling is required according to Regulation No (EC) 1272/2008 (CLP) or Directive 67/548/EEC (DSD) criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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