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EC number: 233-801-0 | CAS number: 10361-92-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 November 2016 - 25 January 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Remarks:
- Minor technical oversights not considered to have impacted the integrity of the study.
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Remarks:
- Minor technical oversights not considered to have impacted the integrity of the study.
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- Remarks:
- Minor technical oversights not considered to have impacted the integrity of the study.
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Yttrium chloride hexahydrate
- Cas Number:
- 10025-94-2
- Molecular formula:
- YCl3.6H2O
- IUPAC Name:
- Yttrium chloride hexahydrate
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of the test material (as cited in the report): yttrium trichloride hexahydrate
- Physical state: solid
- Appearance: white to yellowish crystalline powder
- Further information on test material confidential.
Constituent 1
- Specific details on test material used for the study:
- No correction for purity was applied during the test.
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Crl:(WI)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Research Models and Services, Germany GmbH, Sandhofer Weg 7, D-97633 Sulzfeld, Germany
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: young healthy adult rats, 11-12 weeks old
- Weight at study initiation: 223 – 242 g. Body weight variation did not exceed +/-20% of the sex mean.
- Fasting period before study: 16 hours maximum, overnight
- Housing: Group caging (3 animals/cage), Type II. polypropylene/polycarbonate, “Lignocel 3/4-S Hygienic Animal Bedding” and “Arbocel crinklets natural” nest building material produced by J. Rettenmaier & Söhne GmbH & Co.KG (D-73494 Rosenberg, Germany) were available to animals during the study.
- Diet (e.g. ad libitum): sniff® SM R/M "Autoclavable complete diet for rats and mice – breeding and maintenance" produced by Ssniff Spezialdiäten GmbH, D-59494 Soest Germany (278 5652, expiry date: 30 November 2016 and batch number: 141 8884, expiry date: 31 January 2017), ad libitum
- Water (e.g. ad libitum): municipal tap water, ad libitum
- Acclimation period: at least 28 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.9 – 23.0 ºC
- Humidity (%): 27 - 71%
- Air changes (per hr): 15-20 air exchanges/hour
- Photoperiod (hrs dark / hrs light): 12 hours dark / 12 hours light
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- distilled
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 200 mg/mL
- Amount of vehicle (if gavage): 10 mL/kg bw
- Justification for choice of vehicle: Trial formulations with the test item.
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw
- Doses:
- Single dose, 2000 mg/kg bw
- No. of animals per sex per dose:
- 6 females. Initially, three female animals were treated with 2000 mg/kg bw of the test item. Only 1 animal was found dead on Day 2, therefore a further 3 animals were treated at the dose level of 2000 mg/kg bw.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
*Clinical observations: 30 minutes, then 1, 2, 3, 4 and 6 hours after the treatment and once each day in the morning for 14 consecutive days. Individual observations were performed on the skin and fur, eyes and mucous membranes and also respiratory, circulatory, autonomic and central nervous system, somatomotor activity and behaviour pattern. Particular attention was directed to observation of tremors, convulsions, salivation, diarrhoea, lethargy, sleep and coma.
*The body weight was recorded on the day before treatment (Day -1), on the day of the treatment (Day 0) and weekly thereafter.
- Necropsy of survivors performed: Yes. Macroscopic examination was performed on all animals. The surviving animals were sacrificed by exsanguination under pentobarbital anaesthesia (Euthanimal 40%). After examination of the external appearance, the cranial, thoracic and the abdominal cavities were opened and the organs and the tissues were observed. - Statistics:
- No statistical analysis was performed (the method used is not intended to allow the calculation of a precise LD50 value).
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Two females were found dead on Day 1 and 2.
- Clinical signs:
- other: Decreased activity (slight/moderate), hunched back and piloerection were present in both of the found dead animals up to the point of death. The same symptoms were present in all surviving animals from the day of treatment up to Day 7, with brownish colou
- Gross pathology:
- Found dead animals: In the stomach, diffuse grey/green discoloration of the glandular mucosa, diffuse thickness of the glandular mucosa, clear liquid mixed with digestive contents/diets and dilatation were considered to be test item-related. The changes of the lungs, thymus and urinary bladder were regarded as agonal/post mortem or incidental.
Surviving animals: Red foci of the stomach glandular mucosa seen in 2/4 surviving animals terminated on Day 14, were regarded as test item-related. - Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Under the conditions of this study, the acute oral LD50 value of the test item yttrium trichloride hexahydrate was found to be equal to or above 2000 mg/kg bw in female Crl:WI Wistar rats.
According to the GHS criteria, classification of yttrium trichloride hexahydrate in "Category 5" for acute oral toxicity is appropriate. Under the CLP Regulation, no classification is required.
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