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EC number: 268-776-5 | CAS number: 68140-14-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- It is considered appropriate to address the data requirements for DTO_DETA by read-across to the available studies on the main components of DTO_DETA: AAI_DETA and Rosin.
DTO_DETA and AAI_DETA are each a mixture of constituents which include monoamide, diamide, residual amine and imidazoline (mono-, di- and tri-condensate) chemical structures. The substances therefore have common functional groups based on amide, amine and imidazoline moieties and are sufficiently similar in terms of chemical structure to support a read-across approach.
DTO_DETA contains comparatively lower levels of imidazolines and higher levels of resin acids than AAI_DETA and therefore consideration of data for resin acids is also considered necessary. The main resin acid in DTO_DETA is abietic acid, but abietic acid derivatives and other acids, such as pimaric acid, are also found in notable quantities, and the resin acids collectively are known as ‘rosin’. DTO_DETA contains upto 25% unreacted rosin, and taking into account the compositional information available for the rosin in DTO_DETA and Rosin (CAS# 8050-09-07, EC# 232-475-7), the latter was considered appropriate for read-across to DTO_DETA. Bioaccumulation studies are available for rosins. It is considered appropriate to read across from information on these two substances to DTO_DETA. - Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Type:
- BCF
- Value:
- 130
- Basis:
- whole body w.w.
- Remarks on result:
- other: Neobietic acid / Conc in environment / dose: 0.7 ug/l
- Details on results:
- Imidazoline DETA
Not relevant
Rosins
Fish exposed to 24ug/L total waterborne free acids retained about 2 mg/kg free and 1 mg/kg conjugated acids during the study (Table 1). There were no detectable levels of free or conjugated acids in fish sampled 4 to 10 d after acid exposure stopped, which prevented their half-lives from being calculated. Nevertheless, based on the <25- to 330-ug/kg concentrations of free and <25to 490 ug/kg concentrations of conjugate acids after 20 days of exposure, and the quantitation limit of 25 ug/kg after 4 d post-exposure, it could be suggested that the half-life for these free and conjugated resin acids would be <4 days in trout. BCF values for the eight detected free acids were highest after 10 d and decreased significantly (P≤ 0.05) thereafter (Table 2). A mean BCF for each free acid was estimated from the 14- and 20-d values. Mean BCF values ranged from about 25 for chlorodehydroabietic acid to 130 for neoabietic acid. The 5-day BCF values for some acids were not significantly different from those at 20 day, but they were not used to estimate mean BCF due to differences at the 10-day sample interval. - Validity criteria fulfilled:
- not applicable
- Conclusions:
- Imidazoline DETA
Despite the fact that the log Kow is measured applying the most appropriate method according to the REACH guidance i.e. the slow stirring method (OECD 123), there is unfortunately no reliable relationship between the measured log Kow and BCF for this type of substances. The predicted low bioaccumulation potential is however supported by the low acute to chronic ratio observed in the long-term daphnia test.
Rosins
Rainbow trout (Oncorhynchus mykiss) were exposed to nine resin acids that included abietic, dehydroabietic, chlorodehydroabietic, dichlorodehydroabietic, neoabietic, pimaric, isopimarie, sandaracopimaric, and palustric acids. Bioconcentration factors (BCFs) for these acids ranged from <25 to 130 among fish that were exposed to mean waterborne concentrations of 0.7 to 3.6 ug/L for 20 days. Total free and conjugated acid concentrations ranged from 1 to 3 mg/kg on a wholebody basis. Elimination rates were also monitored over a 10-day deparation period, although no detectable levels were observed. Based on initial chemical concentrations, it was concluded that the half-lives of these acids were < 4 days.
The maximum BCF of 130 is therefore considered appropriate. - Executive summary:
It is considered appropriate to address the data requirements for DTO_DETA by read-across to the available studies on the main components of DTO_DETA: AAI_DETA and Rosin. DTO_DETA and AAI_DETA are each a mixture of constituents which include monoamide, diamide, residual amine and imidazoline (mono-, di- and tri-condensate) chemical structures. The substances therefore have common functional groups based on amide, amine and imidazoline moieties and are sufficiently similar in terms of chemical structure to support a read-across approach. DTO_DETA contains comparatively lower levels of imidazolines and higher levels of resin acids than AAI_DETA and therefore consideration of data for resin acids is also considered necessary. The main resin acid in DTO_DETA is abietic acid, but abietic acid derivatives and other acids, such as pimaric acid, are also found in notable quantities, and the resin acids collectively are known as ‘rosin’. DTO_DETA contains upto 25% unreacted rosin, and taking into account the compositional information available for the rosin in DTO_DETA and Rosin (CAS# 8050-09-07, EC# 232-475-7), the latter was considered appropriate for read-across to DTO_DETA. Bioaccumulation studies are available for rosins. It is considered appropriate to read across from information on these two substances to DTO_DETA.
Reference
Description of key information
Imidazoline DETA
A low bioaccumulation potential is indicated by the measured LogKow,
2.2 and the low acute to chronic ratio in the aquatic studies.
Rosins
Measured BCF values for rosin acids range from <25 to 130 for fish.
Calculated BCF values range from 3.162 to 56.23 L/kg ww and calculated
BAF values range from 1.474 to 694000.
Based on the available data a BCF of 130 L/kg ww is considered
appropriate for the assessment.
Key value for chemical safety assessment
- BCF (aquatic species):
- 130 L/kg ww
Additional information
Imidazoline DETA
Alkyl amidoamines/imidazolines are hydrolyzed and biodegraded and it is therefore unlikely that they will accumulate in the food chain. Since there is a log Kow measured using the slow stirring method according to OECD 123, this value used to predict the bioaccumulation potential. Based on this log Kow value of 2.2, the calculated log BCF is 1.24 (BCF = 17.4 EpiSuite v4.0).
Despite the fact that the log Kow is measured applying the most appropriate method according to the REACH guidance i.e. the slow stirring method (OECD 123), there is unfortunately no reliable relationship between the measured log Kow and BCF for this type of substances. The predicted low bioaccumulation potential is however supported by the low acute to chronic ratio observed in the long-term daphnia test.
Rosins
A study is available with measured BCF values for various resin acids. Resin acids are the predominant components of rosin. Therefore it is considered appropriate to read across from resin acids to members of the category Rosin, Hydrogenated rosin and their salts.
Rainbow trout (Oncorhynchus mykiss) were exposed to nine resin acids that included abietic, dehydroabietic, chlorodehydroabietic, dichlorodehydroabietic, neoabietic, pimaric, isopimaric, sandaracopimaric, and palustric acids. Bioconcentration factors (BCFs) for these acids ranged from <25 to 130 among fish that were exposed to mean waterborne concentrations of 0.7 to 3.6µg/L for 20 days. Total free and conjugated acid concentrations ranged from 1 to 3 mg/kg on a whole body basis. Elimination rates were also monitored over a 10-day depuration period, although no detectable levels were observed. Based on initial chemical concentrations, it was concluded that the half-lives of these acids were < 4 days.
Bioconcentration/bioaccumulation was also estimated for each category member using QSAR estimation software (EPISUITE BCFBAF v3.00), in accordance with REACH Annex XI. The calculated BCF values ranged from 3.162 to 56.23 L/kg ww. Calculated BAF values ranged from 1.474 to 694000.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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