Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 930-930-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
Screening test. Data waiving (study scientifically not necessary): It has been shown that hydrogen peroxide is rapidly metabolised in the body to oxygen and water and does not bioaccumulate. In none of the repeated dose studies described in the dossier, hydrogen peroxide causes directly systemic effects. It is also doubtful whether hydrogen peroxide would reach inner organs as ovaries and testes as well as foetuses to cause reproductive and/or developmental toxicity. It is concluded that reproductive and developmental toxicity studies will not provide any additional useful information for the risk assessment of hydrogen peroxide and should therefore not be conducted due to animal welfare reasons.
Under physiological conditions, calcium oxide ultimately dissociates into Ca2+ and OH-. Calcium, as an essential and abundantly available mineral nutrient, is not deemed to be toxic to reproduction/fertility. OH- is neutralised in body fluids, hence not relevant in terms of toxicity to reproduction/fertility.
EOGRTS. Data waiving (study scientifically not necessary): According to the column 1 of REACH Annex IX, this study does not need to be conducted because the available repeated dose toxicity studies do not indicate adverse effects on reproductive organs or tissues nor reveal any other concern in relation with reproductive toxicity.
Link to relevant study records
- Endpoint:
- screening for reproductive / developmental toxicity
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
It has been shown that hydrogen peroxide is rapidly metabolised in the body to oxygen and water and does not bio-accumulate. In none of the repeated dose studies described in the dossier hydrogen peroxide causes directly systemic effects. It is also doubtful whether hydrogen peroxide would reach inner organs as ovaries and testes as well as foetuses to cause reproductive toxicity. It is concluded that reproductive toxicity studies will not provide any useful information for the risk assessment of hydrogen peroxide and should therefore not be conducted due to animal welfare reasons. - Reproductive effects observed:
- not specified
- Endpoint:
- extended one-generation reproductive toxicity - basic test design (Cohorts 1A, and 1B without extension)
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the extended one-generation reproductive toxicity study does not need to be conducted because there are no results from available repeated dose toxicity studies that indicate adverse effects on reproductive organs or tissues, or reveal other concerns in relation with reproductive toxicity
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
According to the column 1 of REACH Annex IX, the extended one generation reproductive toxicity study does not need to be conducted because the available repeated dose toxicity studies do not indicate adverse effects on reproductive organs or tissues nor reveal any other concern in relation with reproductive toxicity.
Referenceopen allclose all
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effects on developmental toxicity
Description of key information
Data waiving (study scientifically not necessary): It has been shown that hydrogen peroxide is rapidly metabolised in the body to oxygen and water and does not bioaccumulate. In none of the repeated dose studies described in the dossier, hydrogen peroxide causes directly systemic effects. It is also doubtful whether hydrogen peroxide would reach inner organs as ovaries and testes as well as foetuses to cause reproductive and/or developmental toxicity. It is concluded that reproductive and developmental toxicity studies will not provide any additional useful information for the risk assessment of hydrogen peroxide and should therefore not be conducted due to animal welfare reasons.
Link to relevant study records
- Endpoint:
- developmental toxicity
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
It has been shown that hydrogen peroxide is rapidly metabolised in the body to oxygen and water and does not bio-accumulate. In none of the repeated dose studies described in the dossier hydrogen peroxide causes directly systemic effects. It is also doubtful whether hydrogen peroxide would reach inner organs as ovaries and testes as well as foetuses to cause reproductive toxicity. It is concluded that reproductive toxicity studies will not provide any useful information for the risk assessment of hydrogen peroxide and should therefore not be conducted due to animal welfare reasons. - Species:
- rat
- Abnormalities:
- not specified
- Developmental effects observed:
- not specified
Reference
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Mode of Action Analysis / Human Relevance Framework
Calcium peroxide when in contact with water, on the one hand hydrolyses into hydrogen peroxide, and on the other hand results in a loss of active oxygen. Moreover, dissolving calcium peroxide in water, results in an increase of the pH. Under acidic conditions, the water solubility of the reaction mass will be very high because the hydroxide reacts with the acid.
CaO2 + H2O → CaO + H2O2
2CaO2→ 2CaO + O2
2CaO2+ 2H2O → 2Ca2++ 4OH- + O2
The toxicity of the reaction mass is due to the hydrolysis product hydrogen peroxide (H2O2) and calcium hydroxide (Ca(OH)2). Under physiological conditions, calcium hydroxide ultimately dissociates into calcium cations (Ca2 +) and hydroxyl anions (OH-). Calcium, is an essential and abundantly available mineral nutrient. Hydroxyl anion is neutralised in body fluids.
Justification for classification or non-classification
Based on available information, the substance is not classified for toxicity to reproduction according to the CLP Regulation (EC) no. 1272/2008.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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