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Diss Factsheets
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EC number: 203-894-2 | CAS number: 111-67-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995-12-13 to 1995-12-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable without restriction because it was carried out according to Guidelines (EPA 798.4470, OECD 404, 92/69/EEC B.4 and MAFF 59 NohSan No. 4200) and was GLP compliant.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reference substance 001
- Cas Number:
- 111-66-0
- Molecular formula:
- C8H16
- Details on test material:
- - Name of test material (as cited in study report): Gulftene 8
- Substance type: C8 alpha olefin
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 millilitre
- Concentration (if solution): Not reported - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- 6 (5 males, 1 female)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- animal: Mean of animals (1-6)
- Time point:
- 24/48/72 h
- Score:
- ca. 3.42
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- erythema score
- Basis:
- animal: Mean of animals (1-6)
- Time point:
- 24/48/72 h
- Score:
- 1.9
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal: Mean of animals (1-6)
- Time point:
- 24/48/72 h
- Score:
- 1.1
- Reversibility:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating according to EU CLP classification
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The test material application produced a primary irritation index of 3.42 calculated according to US EPA FIFRA guidelines, and mean scores of 1.9 for erythema/eschar formation and 1.1 for edema according to EU labelling restrictions. Compound-induced corrosion was not reported.
- Executive summary:
In a primary dermal irritation study, 5 male and 1 female New Zealand White rabbits were dermally exposed to 0.5 millilitre of Gulftene 8 for 4 hours. Animals then were observed for 14 days and irritation was scored by the Draize method.
The test material application produced a primary irritation index of 3.42 calculated according to US EPA FIFRA guidelines, and mean scores of 1.9 for erythema/eschar formation and 1.1 for edema according to EU labelling restrictions. Compound-induced corrosion was not reported.
This study received a Klimisch score of 1 and is classified as reliable without restriction because it was carried out according to Guidelines (EPA 798.4470, OECD 404, 92/69/EEC B.4 and MAFF 59 NohSan No. 4200) and was GLP compliant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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